Quinine

79 interactions 7 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lefamulin Ketoconazole Topical Colchicine Goserelin Implant Oxaliplatin Injection Alfuzosin

3 Contraindicated 70 Major 4 Moderate 2 Minor

All (79) Contraindicated (3) Major (70) Moderate (4) Minor (2)

Contraindicated

Quinine Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Quinine Ketoconazole Topical Extina® Foam Increased quiNINE exposure and an increased risk of QT interval prolongation Details Quinine Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions, increased sensitive CYP3A4 substrate expos... Details

Major

Quinine Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Quinine Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Quinine Sertraline Explained An increased risk of QT interval prolongation Details Quinine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Quinine Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Quinine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Quinine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation and risk of ventricular arrhythmias Details Quinine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Quinine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation and risk of ventricular arrhythmias Details Quinine Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Quinine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Quinine Azithromycin AzaSite An increased risk of QT interval prolongation Details Quinine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Quinine Anagrelide Agrylin Increased risk of QT interval prolongation Details Quinine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Quinine Brexpiprazole Rexulti Increased brexpiprazole exposure Details Quinine Chloroquine Aralen® An increased risk of QT interval prolongation Details Quinine Cyclosporine Injection Atopica Increased cycloSPORINE exposure and increased quiNINE exposure Details Quinine Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and increased quiNINE exposure Details Quinine Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Quinine Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Quinine Dasatinib Phyrago An increased risk of QT interval prolongation Details Quinine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Quinine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Quinine Digoxin Cardoxin® Increased digoxin exposure Details Quinine Disopyramide Norpace An increased risk of QT interval prolongation Details Quinine Dolasetron Anzemet An increased risk of QT interval prolongation Details Quinine Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Quinine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Quinine Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Quinine Encorafenib Braftovi Increased risk of QT interval prolongation Details Quinine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Quinine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Quinine Fostemsavir Rukobia Increased risk of torsade de pointes Details Quinine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Quinine Gemifloxacin Factive An increased risk of QT interval prolongation Details Quinine Glasdegib Daurismo Increased risk of QT interval prolongation Details

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