Buprenorphine

633 interactions 533 explained in plain English 652 cited references
Also sold as: Belbuca Brixadi Buprenex BuTrans Simbadol Sublocade Zorbium
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Buprenorphine Voclosporin Lupkynis Explained An increased risk of QT interval prolongation Details Buprenorphine Voriconazole Vfend Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Vorinostat Zolinza Explained An increased risk of QT interval prolongation Details Buprenorphine Vortioxetine Trintellix Explained An increased risk of serotonin syndrome Details Buprenorphine Voxelotor Oxbryta Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Xipamide Explained Reduced efficacy of diuretics Details Buprenorphine Zaleplon Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Ziftomenib Komzifti Explained An increased risk of QT interval prolongation and torsade de pointes Details Buprenorphine Zolmitriptan Zomig Explained An increased risk of serotonin syndrome Details Buprenorphine Zolpidem Ambien Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Zopiclone Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Zotepine Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Buprenorphine Zuclopenthixol Explained An increased risk of QT interval prolongation Details Buprenorphine Zuranolone Zurzuvae Explained An increased risk of CNS depression Details Buprenorphine Ethanol Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Trospium / Xanomeline Cobenfy Explained An increased risk of paralytic ileus Details Buprenorphine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Buprenorphine Aripiprazole Injection Abilify An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Buprenorphine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Buprenorphine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Buprenorphine Aclidinium Oral Inhalation Tudorza An increased risk of paralytic ileus Details Buprenorphine Atropine Ophthalmic Atropine Care 1% An increased risk of paralytic ileus Details Buprenorphine Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Cetirizine Injection Aller-Tec An increased risk of respiratory depression and CNS depression Details Buprenorphine Cetirizine Ophthalmic Zerviate An increased risk of respiratory depression and CNS depression Details Buprenorphine Cyclopentolate Ophthalmic Akpentolate® An increased risk of paralytic ileus Details Buprenorphine Cyclosporine Injection Atopica Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Cyclosporine Ophthalmic Cequa Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Buprenorphine Dexamethasone Injection Decadron Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Diazepam Nasal Spray Valtoco An increased risk of CNS depression and respiratory depression Details Buprenorphine Diazepam Rectal Diastat An increased risk of CNS depression and respiratory depression Details Buprenorphine Diphenhydramine Injection Banophen An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Buprenorphine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Buprenorphine Dolasetron Injection Anzemet An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Buprenorphine Eribulin Injection Halaven An increased risk of QT interval prolongation Details Buprenorphine Esketamine Nasal Spray Spravato An increased risk of respiratory depression and CNS depression Details Buprenorphine Famotidine Injection Calmicid An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.