Buprenorphine
633 interactions 533 explained in plain English 652 cited references
Also sold as:
Belbuca
Brixadi
Buprenex
BuTrans
Simbadol
Sublocade
Zorbium
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Buprenorphine Bendroflumethiazide Explained Reduced efficacy of diuretics Details Buprenorphine Benperidol Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Bentazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Benzhydrocodone Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Benzphetamine Explained An increased risk of serotonin syndrome Details Buprenorphine Benzthiazide Explained Reduced efficacy of diuretics Details Buprenorphine Benztropine Explained An increased risk of paralytic ileus Details Buprenorphine Biperiden Explained An increased risk of paralytic ileus Details Buprenorphine Boceprevir Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Bosentan Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Bromazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Bromopride Explained Potentiation of sedative effects Details Buprenorphine Brompheniramine Respa-BR Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Buprenorphine Bumetanide Bumex Explained Reduced efficacy of diuretics Details Buprenorphine Bupropion Aplenzin Explained Increased risk of seizures Details Buprenorphine Buserelin Explained An increased risk of QT interval prolongation Details Buprenorphine Buspirone Bucapsol Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Buprenorphine Butabarbital Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Butalbital Explained An increased risk of CNS depression Details Buprenorphine Butorphanol Butorphic Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Calcium Oxybate Xywav Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Buprenorphine Cannabidiol Epidiolex Explained Increased risk of CNS depression and an increased risk of sedation and somnolence Details Buprenorphine Cannabis Explained Increased buprenorphine and norbuprenorphine (active metabolite) plasma levels Details Buprenorphine Canrenoate Explained Reduced efficacy of diuretics Details Buprenorphine Canrenone Explained Reduced efficacy of diuretics Details Buprenorphine Carbamazepine Carbatrol Explained Reduced buprenorphine exposure, reduced efficacy of buprenorphine, an increased risk of serotonin syndrome and an increased risk o... Details Buprenorphine Carbidopa Lodosyn Explained An increased risk of CNS depression Details Buprenorphine Carbinoxamine Carbzah Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Buprenorphine Cariprazine Vraylar Explained Increased risk of respiratory and CNS depression Details Buprenorphine Carisoprodol Soma Explained Enhanced neuromuscular blocking action, an increased risk of respiratory depression and CNS depression and an increased risk of pa... Details Buprenorphine Carphenazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Cenobamate Xcopri Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Ceritinib Zykadia Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Cetirizine Aller-Tec Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Chloral Hydrate Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Chlordiazepoxide Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Chloroquine Aralen® An increased risk of QT interval prolongation Details Buprenorphine Chlorothiazide Diuril Explained Reduced efficacy of diuretics Details Buprenorphine Chlorpheniramine Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Buprenorphine Chlorpromazine Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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