Buprenorphine
633 interactions 533 explained in plain English 652 cited references
Also sold as:
Belbuca
Brixadi
Buprenex
BuTrans
Simbadol
Sublocade
Zorbium
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Buprenorphine Butalbital Explained An increased risk of CNS depression Details Buprenorphine Butorphanol Butorphic Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Calcium Oxybate Xywav Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Buprenorphine Cannabidiol Epidiolex Explained Increased risk of CNS depression and an increased risk of sedation and somnolence Details Buprenorphine Cannabis Explained Increased buprenorphine and norbuprenorphine (active metabolite) plasma levels Details Buprenorphine Canrenoate Explained Reduced efficacy of diuretics Details Buprenorphine Canrenone Explained Reduced efficacy of diuretics Details Buprenorphine Carbamazepine Carbatrol Explained Reduced buprenorphine exposure, reduced efficacy of buprenorphine, an increased risk of serotonin syndrome and an increased risk o... Details Buprenorphine Carbidopa Lodosyn Explained An increased risk of CNS depression Details Buprenorphine Carbinoxamine Carbzah Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Buprenorphine Cariprazine Vraylar Explained Increased risk of respiratory and CNS depression Details Buprenorphine Carisoprodol Soma Explained Enhanced neuromuscular blocking action, an increased risk of respiratory depression and CNS depression and an increased risk of pa... Details Buprenorphine Carphenazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Cenobamate Xcopri Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Ceritinib Zykadia Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Cetirizine Aller-Tec Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Chloral Hydrate Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Chlordiazepoxide Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Chloroquine Aralen® An increased risk of QT interval prolongation Details Buprenorphine Chlorothiazide Diuril Explained Reduced efficacy of diuretics Details Buprenorphine Chlorpheniramine Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Buprenorphine Chlorpromazine Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Buprenorphine Chlorthalidone Hemiclor Explained Reduced efficacy of diuretics Details Buprenorphine Chlorzoxazone Lorzone Explained Enhanced neuromuscular blocking action and an increased risk of respiratory depression and CNS depression Details Buprenorphine Cimetidine Tagamet Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Ciprofloxacin Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Citalopram Celexa Explained An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Buprenorphine Clarithromycin Biaxin Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Clemastine Clemasz Explained An increased risk of paralytic ileus Details Buprenorphine Clidinium Explained An increased risk of paralytic ileus Details Buprenorphine Clobazam Onfi Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Clofazimine Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Clomipramine Anafranil Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome, an increased risk of paralytic ileus and a... Details Buprenorphine Clonazepam Klonopin Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Clopamide Explained Reduced efficacy of diuretics Details Buprenorphine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Buprenorphine Clorazepate Tranxene Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Clothiapine Explained Increased risk of cardiac arrhythmias Details Buprenorphine Cloxazolam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Clozapine Clozaril Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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