Buprenorphine
633 interactions 533 explained in plain English 652 cited references
Also sold as:
Belbuca
Brixadi
Buprenex
BuTrans
Simbadol
Sublocade
Zorbium
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Buprenorphine Lorcaserin Explained An increased risk of serotonin syndrome Details Buprenorphine Lorlatinib Lorbrena Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Lormetazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Loxapine Adasuve Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Buprenorphine Lumacaftor Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Lumefantrine Explained An increased risk of QT interval prolongation Details Buprenorphine Lurasidone Latuda Increased risk of respiratory and CNS depression Details Buprenorphine Macimorelin Explained Increased risk of QT interval prolongation Details Buprenorphine Magnesium Oxybate Xywav Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Buprenorphine Mavorixafor Xolremdi Explained An increased risk of QT interval prolongation and torsade de pointes Details Buprenorphine Meclizine Antivert Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Buprenorphine Medazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Mefloquine Lariam® An increased risk of QT interval prolongation Details Buprenorphine Melitracen Explained An increased risk of serotonin syndrome Details Buprenorphine Melperone Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Mepenzolate Explained An increased risk of paralytic ileus Details Buprenorphine Meperidine Demerol Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Mephobarbital Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Meprobamate Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Meptazinol Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Buprenorphine Metaclazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Metaxalone Skelaxin Explained Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Buprenorphine Methadone Diskets Explained Reduced analgesic effect or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome, an increased risk of re... Details Buprenorphine Methamphetamine Desoxyn Explained An increased risk of serotonin syndrome Details Buprenorphine Methdilazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Methocarbamol Atmeksi Explained Enhanced neuromuscular blocking action and an increased risk of respiratory depression and CNS depression Details Buprenorphine Methohexital Brevital Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Methotrimeprazine Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Buprenorphine Methyclothiazide Explained Reduced efficacy of diuretics Details Buprenorphine Methylene Blue Provayblue Explained An increased risk of CNS depression and an increased risk of serotonin syndrome or opioid toxicity Details Buprenorphine Metoclopramide Explained Increased risk of CNS depression Details Buprenorphine Metolazone Explained Reduced efficacy of diuretics Details Buprenorphine Metronidazole Flagyl An increased risk of QT interval prolongation Details Buprenorphine Midazolam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Mifepristone Korlym Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Milnacipran Savella Explained An increased risk of serotonin syndrome Details Buprenorphine Milsaperidone Explained An increased risk of QT interval prolongation Details Buprenorphine Mirtazapine Mirataz Explained Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Buprenorphine Mitotane Lysodren Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Mizolastine Explained An increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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