Buprenorphine

633 interactions 533 explained in plain English 652 cited references
Also sold as: Belbuca Brixadi Buprenex BuTrans Simbadol Sublocade Zorbium
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Buprenorphine Meprobamate Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Meptazinol Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Buprenorphine Metaclazepam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Metaxalone Skelaxin Explained Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Buprenorphine Methadone Diskets Explained Reduced analgesic effect or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome, an increased risk of re... Details Buprenorphine Methamphetamine Desoxyn Explained An increased risk of serotonin syndrome Details Buprenorphine Methdilazine Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Methocarbamol Atmeksi Explained Enhanced neuromuscular blocking action and an increased risk of respiratory depression and CNS depression Details Buprenorphine Methohexital Brevital Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Methotrimeprazine Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Buprenorphine Methyclothiazide Explained Reduced efficacy of diuretics Details Buprenorphine Methylene Blue Provayblue Explained An increased risk of CNS depression and an increased risk of serotonin syndrome or opioid toxicity Details Buprenorphine Metoclopramide Explained Increased risk of CNS depression Details Buprenorphine Metolazone Explained Reduced efficacy of diuretics Details Buprenorphine Metronidazole Flagyl An increased risk of QT interval prolongation Details Buprenorphine Midazolam Explained An increased risk of CNS depression and respiratory depression Details Buprenorphine Mifepristone Korlym Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Milnacipran Savella Explained An increased risk of serotonin syndrome Details Buprenorphine Milsaperidone Explained An increased risk of QT interval prolongation Details Buprenorphine Mirtazapine Mirataz Explained Increased risk of serotonin syndrome, an increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Buprenorphine Mitotane Lysodren Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Mizolastine Explained An increased risk of QT interval prolongation Details Buprenorphine Mobocertinib Exkivity Explained An increased risk of QT interval prolongation Details Buprenorphine Modafinil Provigil Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Molindone Explained An increased risk of respiratory depression and CNS depression Details Buprenorphine Moricizine Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Buprenorphine Morphine Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Morphine Sulfate Liposome Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Moxifloxacin Avelox An increased risk of QT interval prolongation Details Buprenorphine Nafarelin Explained An increased risk of QT interval prolongation Details Buprenorphine Nafcillin Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Nalbuphine Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Buprenorphine Naratriptan Explained An increased risk of serotonin syndrome Details Buprenorphine Nefazodone Explained An increased risk of serotonin syndrome, increased buprenorphine exposure and an increased risk of buprenorphine-related adverse e... Details Buprenorphine Nelfinavir Viracept Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Netupitant Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Nevirapine Viramune Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Nicomorphine Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Buprenorphine Nilotinib Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Buprenorphine Nitrazepam Explained An increased risk of CNS depression and respiratory depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.