Bupropion

117 interactions 4 explained in plain English
Also sold as: Aplenzin Aplenzin® Budeprion® SR Budeprion® XL Buproban® Forfivo Forfivo® XL Wellbutrin Wellbutrin® Wellbutrin® SR Wellbutrin® XL Zyban®
About Bupropion

Bupropion is an antidepressant used to treat depression, seasonal affective disorder, and to help people quit smoking. Read the full Bupropion drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Nebivolol Dopamine Famotidine Acyclovir Penicillin V Potassium
1 Contraindicated 114 Major 2 Moderate
All (117) Contraindicated (1) Major (114) Moderate (2)

Major

Bupropion Mefenamic Acid Ponstel® Increased risk of seizures Details Bupropion Mefloquine Lariam® Increased risk of seizures Details Bupropion Memantine Namenda Reduced renal clearance of OCT2 substrates Details Bupropion Meropenem Increased risk of seizures Details Bupropion Meropenem Injection Merrem® Increased risk of seizures Details Bupropion Metformin Fortamet® Reduced renal clearance of OCT2 substrates Details Bupropion Methimazole Felanorm An increased risk of hepatotoxicity Details Bupropion Methylphenidate Adhansia XR® Increased risk of seizures Details Bupropion Methylphenidate Transdermal Patch Daytrana Increased risk of seizures Details Bupropion Metoclopramide Injection Gimoti Increased metoclopramide exposure and risk of increased adverse events Details Bupropion Metoclopramide Nasal Spray Gimoti Increased metoclopramide exposure and risk of increased adverse events Details Bupropion Metronidazole Flagyl Increased risk of seizures Details Bupropion Metronidazole Injection Flagyl Increased risk of seizures Details Bupropion Metronidazole Topical MetroCream® Increased risk of seizures Details Bupropion Metronidazole Vaginal MetroGel® Vaginal Increased risk of seizures Details Bupropion Mexiletine Mexitil® Increased exposure of CYP2D6 substrates Details Bupropion Midostaurin Rydapt Decreased CYP2B6-substrate exposure Details Bupropion Morphine Injection Astramorph® PF Increased risk of seizures Details Bupropion Moxifloxacin Avelox Increased risk of seizures Details Bupropion Moxifloxacin Injection Avelox Increased risk of seizures Details Bupropion Moxifloxacin Ophthalmic Moxeza® Increased risk of seizures Details Bupropion Nafcillin Injection Unipen® Injection Increased risk of seizures Details Bupropion Nalbuphine Injection Nubain® Increased risk of seizures Details Bupropion Nebivolol Bystolic Increased exposure to nebivolol Details Bupropion Neostigmine Methylsulfate Bloxiverz Increased risk of seizures Details Bupropion Nevirapine Viramune Reduced buPROPion and hydroxybuPROPion exposure Details Bupropion Ofloxacin Floxin® Increased risk of seizures Details Bupropion Ofloxacin Ophthalmic Ocuflox Increased risk of seizures Details Bupropion Ofloxacin Otic Floxin® Otic Increased risk of seizures Details Bupropion Olopatadine Pataday Increased risk of seizures Details Bupropion Olopatadine Nasal Spray PATANASE Increased risk of seizures Details Bupropion Oxaliplatin Injection Eloxatin® Reduced renal clearance of OCT2 substrates Details Bupropion Oxandrolone Oxandrin Lowering of the seizure threshold Details Bupropion Penicillin V Potassium Beepen-VK® Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.