Cabotegravir

54 interactions 20 cited references
Also sold as: Apretude Vocabria Vocabria®
About Cabotegravir

Cabotegravir is used along with rilpivirine (Edurant) as a short-term treatment of human immunodeficiency virus type 1 (HIV-1) infection in certain adults and adolescents 12 years of age or older weighing at least 77 pounds (35 kg). Cabotegravir is used as a short-term prevention of human immunodeficiency virus type 1… Read the full Cabotegravir drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Carbamazepine Rifampin Rifabutin Phenytoin Phenobarbital Oxcarbazepine
7 Contraindicated 47 Major
All (54) Contraindicated (7) Major (47)

Contraindicated

Cabotegravir Carbamazepine Carbatrol May significantly reduce cabotegravir plasma concentrations and result in loss of virological response. Details Cabotegravir Oxcarbazepine Oxtellar Decreased cabotegravir plasma concentrations with possible loss of virologic response Details Cabotegravir Phenobarbital Fidoquel Decreased cabotegravir plasma concentrations with possible loss of virologic response Details Cabotegravir Phenytoin Dilantin Decreased cabotegravir plasma concentrations with possible loss of virologic response Details Cabotegravir Rifabutin Mycobutin An increased risk of drug-drug interactions Details Cabotegravir Rifampin Rifadin Decreased cabotegravir plasma concentration with loss of virologic response. Details Cabotegravir Rifapentine Priftin Decreased cabotegravir plasma concentration with loss of virologic response. Details

Major

Cabotegravir Abacavir Ziagen Loss of virologic response and possible development of viral resistance Details Cabotegravir Aluminum Carbonate, Basic Reduced cabotegravir plasma concentrations Details Cabotegravir Aluminum Hydroxide AlternaGEL® Reduced cabotegravir plasma concentrations Details Cabotegravir Aluminum Phosphate Reduced cabotegravir plasma concentrations Details Cabotegravir Amprenavir Loss of virologic response and possible development of viral resistance Details Cabotegravir Atazanavir Reyataz Loss of virologic response and possible development of viral resistance Details Cabotegravir Atidarsagene Autotemcel Lenmeldy Interference with the manufacturing of atidarsagene autotemcel Details Cabotegravir Calcium Carbonate Alka-Mints Reduced cabotegravir plasma concentrations Details Cabotegravir Darunavir Loss of virologic response and possible development of viral resistance Details Cabotegravir Delavirdine Rescriptor® Loss of virologic response and possible development of viral resistance Details Cabotegravir Didanosine Videx® Loss of virologic response and possible development of viral resistance Details Cabotegravir Dihydroxyaluminum Aminoacetate Reduced cabotegravir plasma concentrations Details Cabotegravir Dihydroxyaluminum Sodium Carbonate Reduced cabotegravir plasma concentrations Details Cabotegravir Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Loss of virologic response and possible development of viral resistance Details Cabotegravir Doravirine Pifeltro Loss of virologic response and possible development of viral resistance Details Cabotegravir Efavirenz Loss of virologic response and possible development of viral resistance Details Cabotegravir Elvitegravir Loss of virologic response and possible development of viral resistance Details Cabotegravir Emtricitabine Emtriva Loss of virologic response and possible development of viral resistance Details Cabotegravir Enfuvirtide Loss of virologic response and possible development of viral resistance Details Cabotegravir Etravirine Intelence Loss of virologic response and possible development of viral resistance Details Cabotegravir Etuvetidigene Autotemcel An increased risk of interference with the manufacturing of etuvetidigene autotemcel Details Cabotegravir Fosamprenavir Lexiva Loss of virologic response and possible development of viral resistance Details Cabotegravir Fostemsavir Rukobia Loss of virologic response and possible development of viral resistance Details Cabotegravir Ibalizumab-Uiyk Loss of virologic response and possible development of viral resistance Details Cabotegravir Indinavir Loss of virologic response and possible development of viral resistance Details Cabotegravir Lamivudine Epivir Loss of virologic response and possible development of viral resistance Details Cabotegravir Lopinavir Loss of virologic response and possible development of viral resistance Details Cabotegravir Magaldrate Reduced cabotegravir plasma concentrations Details Cabotegravir Magnesium Carbonate Reduced cabotegravir plasma concentrations Details Cabotegravir Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Reduced cabotegravir plasma concentrations Details Cabotegravir Magnesium Oxide Mag-Ox 400 Reduced cabotegravir plasma concentrations Details Cabotegravir Magnesium Trisilicate Reduced cabotegravir plasma concentrations Details Cabotegravir Maraviroc Selzentry Loss of virologic response and possible development of viral resistance Details

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