Cabozantinib

93 interactions 301 cited references
Also sold as: Cabometyx Cabometyx® Cometriq Cometriq®
About Cabozantinib

Cabozantinib (Cabometyx, Cometriq) is used to treat a number of conditions. Cabozantinib (Cabometyx) is used: to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the cells of the kidneys). in combination with nivolumab (Opdivo) to treat advanced RCC in patients who have not yet received a treat… Read the full Cabozantinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Ensitrelvir Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live
10 Contraindicated 78 Major 5 Moderate
All (93) Contraindicated (10) Major (78) Moderate (5)

Contraindicated

Cabozantinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Cabozantinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Cabozantinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Cabozantinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Cabozantinib Abametapir Increased exposure of CYP3A4 substrate Details Cabozantinib Adagrasib Krazati Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Cabozantinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Cabozantinib Apalutamide Erleada Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Avacopan Tavneos Increased CYP3A4 substrate exposure Details Cabozantinib Boceprevir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Bosentan Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Carbamazepine Carbatrol Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Cenobamate Xcopri Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Ceritinib Zykadia Increased CYP3A substrate exposure Details Cabozantinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Cabozantinib Clarithromycin Biaxin Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Cobicistat Tybost Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Conivaptan Vaprisol Increased cabozantinib exposure Details Cabozantinib Dabrafenib Tafinlar Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Dipyrone Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Efavirenz Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Elagolix Orilissa Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Encorafenib Braftovi Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Enzalutamide Xtandi Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Cabozantinib Etravirine Intelence Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Cabozantinib Fexinidazole An increased CYP3A4 substrate exposure Details Cabozantinib Fosnetupitant Increased exposure of CYP3A4 substrate Details Cabozantinib Fosphenytoin Cerebyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Idelalisib Zydelig Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Indinavir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.