Cabozantinib (Thyroid Cancer)

90 interactions 301 cited references

Also sold as: Cabometyx Cometriq Cometriq®

About Cabozantinib (Thyroid Cancer)

Cabozantinib (Cometriq) is used to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body. Cabozantinib (Cometriq) is in a class of medications called tyrosine kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to mult… Read the full Cabozantinib (Thyroid Cancer) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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10 Contraindicated 75 Major 5 Moderate

All (90) Contraindicated (10) Major (75) Moderate (5)

Major

Cabozantinib (Thyroid Cancer) Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Itraconazole Sporanox Increased cabozantinib exposure Details Cabozantinib (Thyroid Cancer) Ivosidenib Tibsovo Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Ketoconazole Extina Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Lesinurad Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Letermovir Prevymis Increased CYP3A substrate exposure Details Cabozantinib (Thyroid Cancer) Lonafarnib Zokinvy Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Lopinavir Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Lorlatinib Lorbrena Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Lumacaftor Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Mifepristone Korlym Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Mitapivat Aqvesme Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Mitotane Lysodren Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Modafinil Provigil Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Nafcillin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Nefazodone Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Nelfinavir Viracept Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Netupitant Increased exposure of CYP3A4 substrate Details Cabozantinib (Thyroid Cancer) Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Cabozantinib (Thyroid Cancer) Paritaprevir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Pexidartinib Turalio Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Phenobarbital Fidoquel Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Cabozantinib (Thyroid Cancer) Phenytoin Dilantin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Posaconazole Noxafil Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Primidone Mysoline Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Cabozantinib (Thyroid Cancer) Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Cabozantinib (Thyroid Cancer) Repotrectinib Augtyro Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Ribociclib Kisqali Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Rifabutin Mycobutin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Rifampin Rifadin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Rifapentine Priftin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Ritonavir Norvir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Saquinavir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Sotorasib Lumakras Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) St John's Wort Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Cabozantinib (Thyroid Cancer) Telaprevir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Telithromycin Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Telotristat Ethyl Xermelo Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.