Cabozantinib (Thyroid Cancer)

90 interactions 301 cited references

Also sold as: Cabometyx Cometriq Cometriq®

About Cabozantinib (Thyroid Cancer)

Cabozantinib (Cometriq) is used to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body. Cabozantinib (Cometriq) is in a class of medications called tyrosine kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to mult… Read the full Cabozantinib (Thyroid Cancer) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dengue Tetravalent Vaccine, Live Ensitrelvir Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Yellow Fever Vaccine

10 Contraindicated 75 Major 5 Moderate

All (90) Contraindicated (10) Major (75) Moderate (5)

Major

Cabozantinib (Thyroid Cancer) Abametapir Increased exposure of CYP3A4 substrate Details Cabozantinib (Thyroid Cancer) Adagrasib Krazati Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Apalutamide Erleada Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Avacopan Tavneos Increased CYP3A4 substrate exposure Details Cabozantinib (Thyroid Cancer) Boceprevir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Bosentan Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Carbamazepine Carbatrol Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Cenobamate Xcopri Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Ceritinib Zykadia Increased CYP3A substrate exposure Details Cabozantinib (Thyroid Cancer) Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Clarithromycin Biaxin Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Cobicistat Tybost Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Conivaptan Vaprisol Increased cabozantinib exposure Details Cabozantinib (Thyroid Cancer) Dabrafenib Tafinlar Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Dipyrone Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Efavirenz Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Elagolix Orilissa Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Encorafenib Braftovi Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Enzalutamide Xtandi Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Cabozantinib (Thyroid Cancer) Etravirine Intelence Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Cabozantinib (Thyroid Cancer) Fexinidazole An increased CYP3A4 substrate exposure Details Cabozantinib (Thyroid Cancer) Fosnetupitant Increased exposure of CYP3A4 substrate Details Cabozantinib (Thyroid Cancer) Fosphenytoin Cerebyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Idelalisib Zydelig Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Indinavir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib (Thyroid Cancer) Itraconazole Sporanox Increased cabozantinib exposure Details Cabozantinib (Thyroid Cancer) Ivosidenib Tibsovo Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Ketoconazole Extina Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Lesinurad Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Letermovir Prevymis Increased CYP3A substrate exposure Details Cabozantinib (Thyroid Cancer) Lonafarnib Zokinvy Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib (Thyroid Cancer) Lopinavir Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Lorlatinib Lorbrena Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib (Thyroid Cancer) Lumacaftor Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.