Cabozantinib

93 interactions 301 cited references
Also sold as: Cabometyx Cabometyx® Cometriq Cometriq®
About Cabozantinib

Cabozantinib (Cabometyx, Cometriq) is used to treat a number of conditions. Cabozantinib (Cabometyx) is used: to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the cells of the kidneys). in combination with nivolumab (Opdivo) to treat advanced RCC in patients who have not yet received a treat… Read the full Cabozantinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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10 Contraindicated 78 Major 5 Moderate
All (93) Contraindicated (10) Major (78) Moderate (5)

Major

Cabozantinib Mifepristone Korlym Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Mitapivat Aqvesme Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Mitotane Lysodren Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Modafinil Provigil Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Nafcillin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Nefazodone Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Nelfinavir Viracept Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Netupitant Increased exposure of CYP3A4 substrate Details Cabozantinib Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Cabozantinib Paritaprevir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Pexidartinib Turalio Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Phenobarbital Fidoquel Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Cabozantinib Phenytoin Dilantin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Posaconazole Noxafil Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Primidone Mysoline Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Cabozantinib Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Cabozantinib Repotrectinib Augtyro Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Ribociclib Kisqali Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Rifabutin Mycobutin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Rifampin Rifadin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Rifapentine Priftin Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Ritonavir Norvir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Cabozantinib Saquinavir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Sotorasib Lumakras Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib St John's Wort Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Cabozantinib Telaprevir Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Telithromycin Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Telotristat Ethyl Xermelo Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Thioridazine Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Cabozantinib Troleandomycin Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Tucatinib Tukysa Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Voriconazole Vfend Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Warfarin Coumadin Increased risk of bleeding Details Cabozantinib Ketoconazole Topical Extina® Foam Increased cabozantinib exposure and an increased risk of cabozantinib-related adverse reactions Details Cabozantinib Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Cabozantinib Nafcillin Injection Unipen® Injection Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.