Cefdinir and Typhoid Vaccine, Live: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cefdinir
Typhoid Vaccine, Live
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
A decreased immunological response to the typhoid vaccine
Interaction Deep Dive
Antibiotics which possess bacterial activity against salmonella typhi organisms may interfere with the immunological response to the live typhoid vaccine. Allow 24 hours or more to elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine12.
Why it happens (mechanism)
Antimicrobial activity against the salmonella typhi organism
Common questions
Can I take Cefdinir and Typhoid Vaccine, Live together?
A decreased immunological response to the typhoid vaccine Always confirm with your pharmacist or prescriber before making any change.
How serious is the Cefdinir and Typhoid Vaccine, Live interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Cefdinir or Typhoid Vaccine, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: Vivotif Berna(R) Vaccine, typhoid vaccine live oral ty21a. Berna Products, Corp. Coral Gables, FL, 1997.
- CDC: Typhoid immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1994; 43(RR14):1-7. DOI
Keep reading about Cefdinir
Keep reading about Typhoid Vaccine, Live
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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