Cefdinir

42 interactions 84 cited references

Also sold as: Omnicef®

About Cefdinir

Cefdinir is a cephalosporin antibiotic used to treat bacterial infections including bronchitis, pneumonia, and infections of the skin, ears, sinuses, throat, and tonsils. Read the full Cefdinir drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Cholera Vaccine, Live Desogestrel Methotrexate Injection Levonorgestrel Intrauterine System Exenatide Injection

27 Major 14 Moderate 1 Minor

All (42) Major (27) Moderate (14) Minor (1)

Major

Cefdinir Azathioprine Azasan An increased risk of hepatotoxicity Details Cefdinir Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Cefdinir Desogestrel Decreased contraceptive effectiveness Details Cefdinir Dienogest Decreased contraceptive effectiveness Details Cefdinir Drospirenone Decreased contraceptive effectiveness Details Cefdinir Estradiol Delestrogen Decreased contraceptive effectiveness Details Cefdinir Ethinyl Estradiol Decreased contraceptive effectiveness Details Cefdinir Ethynodiol Decreased contraceptive effectiveness Details Cefdinir Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefdinir Furosemide Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefdinir Gestodene Decreased contraceptive effectiveness Details Cefdinir Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Cefdinir Levonorgestrel After banger Decreased contraceptive effectiveness Details Cefdinir Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Cefdinir Mestranol Decreased contraceptive effectiveness Details Cefdinir Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cefdinir Nomegestrol Decreased contraceptive effectiveness Details Cefdinir Norethindrone Aygestin Decreased contraceptive effectiveness Details Cefdinir Norgestimate Decreased contraceptive effectiveness Details Cefdinir Norgestrel Decreased contraceptive effectiveness Details Cefdinir Warfarin Coumadin An increased risk of bleeding Details Cefdinir Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cefdinir Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cefdinir Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefdinir Furosemide Injection Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefdinir Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Cefdinir Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Cefdinir Aluminum Carbonate, Basic Decreased cefdinir efficacy Details Cefdinir Aluminum Hydroxide AlternaGEL® Decreased cefdinir efficacy Details Cefdinir Aluminum Phosphate Decreased cefdinir efficacy Details Cefdinir Dihydroxyaluminum Aminoacetate Decreased cefdinir efficacy Details Cefdinir Dihydroxyaluminum Sodium Carbonate Decreased cefdinir efficacy Details Cefdinir Iron Decreased cefdinir efficacy; formation of reddish stools Details Cefdinir Lixisenatide Delayed therapeutic effect Details Cefdinir Magaldrate Decreased cefdinir efficacy Details Cefdinir Magnesium Carbonate Decreased cefdinir efficacy Details Cefdinir Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased cefdinir efficacy Details Cefdinir Magnesium Oxide Mag-Ox 400 Decreased cefdinir efficacy Details Cefdinir Magnesium Trisilicate Decreased cefdinir efficacy Details Cefdinir Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.