Drug Interaction Report

Cefdinir and Lixisenatide: Interaction Details

Name: Cefdinir and Lixisenatide Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Cefdinir and Lixisenatide interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Lixisenatide

No brand names on record

Cefdinir

Omnicef®

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 42 documented Cefdinir interactions, 14 are rated moderate — including this one.

Onset

rapid

Evidence

theoretical

Severity

Moderate

What happens

Delayed therapeutic effect

Interaction Deep Dive

Concomitant use of lixisenatide and oral antibiotics may slow the absorption of the antibiotic due to delayed gastric emptying. If concomitant use of these agents is required, administer the oral antibiotic at least one hour before the lixisenatide injection in order to attain threshold concentrations of the antibiotic necessary for efficacy¹.

Why it happens (mechanism)

Delayed gastric emptying

Common questions

Can I take Cefdinir and Lixisenatide together?

Delayed therapeutic effect Always confirm with your pharmacist or prescriber before making any change.

How serious is the Cefdinir and Lixisenatide interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Cefdinir or Lixisenatide need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (1)

Product Information: ADLYXIN(TM) subcutaneous injection, lixisenatide subcutaneous injection. sanofi-aventis US LLC (per manufacturer), Bridgewater, NJ, 2016. DailyMed

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Lixisenatide

Keep reading about Lixisenatide

All Lixisenatide interactions (80)

Also serious with: Ofloxacin Ophthalmic Chloroquine Levofloxacin Estradiol Topical

Cefdinir

Keep reading about Cefdinir

All Cefdinir interactions (42) Cefdinir drug information

Also serious with: Azathioprine Methotrexate Injection Levonorgestrel Intrauterine System Exenatide Injection

Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Lixisenatide + Siberian Cocklebur Acai African Wild Potato Agaricus Mushroom Agmatine Agrimony Alfalfa Algal Oil + 231 more

Cefdinir + Activated Charcoal Asarabacca Siberian Cocklebur African Wild Potato Aristolochia Bacillus Coagulans Bacillus Subtilis Banderol + 52 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.