Lixisenatide

80 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Chloroquine Gemifloxacin Hydroxychloroquine Ofloxacin Ophthalmic Estradiol Topical
26 Major 54 Moderate
All (80) Major (26) Moderate (54)

Major

Lixisenatide Abiraterone Abirtega An increased risk of severe hypoglycemia Details Lixisenatide Chloroquine Aralen® Hypoglycemia Details Lixisenatide Delafloxacin Baxdela Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Delafloxacin Injection Baxdela Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Estradiol Delestrogen Decreased absorption of oral contraceptives Details Lixisenatide Estradiol Topical Divigel Decreased absorption of oral contraceptives Details Lixisenatide Estradiol Transdermal Patch Alora® Decreased absorption of oral contraceptives Details Lixisenatide Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Lixisenatide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Gemifloxacin Factive Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Glimepiride Amaryl Increased risk of hypoglycemia Details Lixisenatide Glipizide Glucotrol Increased risk of hypoglycemia Details Lixisenatide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Lixisenatide Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Lixisenatide Levofloxacin Levaquin Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Levofloxacin Injection Levaquin Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Levonorgestrel After banger Decreased absorption of oral contraceptives Details Lixisenatide Levonorgestrel Intrauterine System Kyleena Decreased absorption of oral contraceptives Details Lixisenatide Moxifloxacin Avelox Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Moxifloxacin Injection Avelox Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Lixisenatide Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Lixisenatide Ofloxacin Floxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Lixisenatide Ofloxacin Otic Floxin® Otic Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details

Moderate

Lixisenatide Acetaminophen And Codeine Capital® & Codeine Explained Slowed absorption of acetaminophen Details Lixisenatide Clindamycin ANTIROBE Explained Delayed therapeutic effect Details Lixisenatide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Lixisenatide Acetaminophen Acephen Slowed absorption of acetaminophen Details Lixisenatide Acetaminophen Injection Acephen Slowed absorption of acetaminophen Details Lixisenatide Acetaminophen Rectal Acephen Slowed absorption of acetaminophen Details Lixisenatide Amoxicillin Amoxi Drop Delayed therapeutic effect Details Lixisenatide Ampicillin Amcill® Delayed therapeutic effect Details Lixisenatide Ampicillin Injection Omnipen-N® Delayed therapeutic effect Details Lixisenatide Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Lixisenatide Benznidazole Delayed therapeutic effect Details Lixisenatide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Lixisenatide Benazepril Lotensin An increased risk of hypoglycemia Details Lixisenatide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.