Drug & supplement interaction

Atkins Diet + Lixisenatide

Lixisenatide brand name: Adlyxin.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Atkins Diet has a minor interaction with Lixisenatide. Theoretically, following the Atkins diet might have additive hypoglycemic effects.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Atkins Diet and Lixisenatide

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIDIABETES DRUGS

Why this applies to Lixisenatide

Lixisenatide falls under ANTIDIABETES DRUGS — the group Atkins Diet interacts with.

Theoretically, following the Atkins diet might have additive hypoglycemic effects.
Following the Atkins diet while taking antidiabetes drugs might increase the risk of hypoglycemia. In patients with diabetes, low-carbohydrate diets such as the Atkins diet can reduce the need for antidiabetes drugs; monitor blood glucose closely.
Severity Minor Likelihood Unlikely Evidence C

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the practical takeaway: cutting carbs sharply, like on the Atkins plan, naturally pulls your blood sugar down. Lixisenatide (Adlyxin) is already working to lower blood sugar by helping your pancreas release insulin around meals. Stack those two together and the effects can add up, so your blood sugar may run lower than you expect. Watch for shakiness, sweating, dizziness, confusion, or a racing heart, which are the usual signs of a low.

This is mostly a theoretical concern based on expert opinion, and lows from lixisenatide alone are uncommon, especially when it's not paired with insulin or a sulfonylurea. Still, if you're starting Atkins, check your sugars more often and let your doctor or pharmacist know, since your medication dose may need adjusting.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kirkpatrick CF, Bolick JP, Kris-Etherton PM, et al. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometaboli

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Atkins Diet Also Interacts With Other Medications

Atkins Diet has 85 minor known drug interactions in our database — the Lixisenatide one above is one of them. If you take anything else, check it against the full list below.

Minor 85 No known interaction 2,745 (incl. Lixisenatide)
Taking anything else?

Check Another of Your Medications Against Atkins Diet

Covers the 2,830 medications we’ve checked against Atkins Diet. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Lixisenatide

This page covers Atkins Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lixisenatide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Lixisenatide page

“Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds…”

Reviewed by 2 · Jul 18, 2026

Open the Lixisenatide interaction page

How much people look this up

Where Atkins Diet and Lixisenatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Atkins Diet
Steady interest

#840 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lixisenatide
Steady interest

#1,899 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Eating pattern

About Atkins Diet

What is Atkins Diet?

  • Weight loss
  • Blood sugar control
  • Reducing carbohydrate intake
  • Improving certain cholesterol markers
  • Appetite control

The Atkins Diet is a low-carbohydrate eating plan that can help some people lose weight and improve blood sugar in the short term. Long-term results often match other diets, and the plan is restrictive and may not suit everyone. Talk with your doctor or pharmacist before starting, especially if you have diabetes, kidney, or heart concerns.

Read the full Atkins Diet monograph & all interactions
Medication

About Lixisenatide Injection

What Is Lixisenatide Injection Used For?

Brand name: Adlyxin

  • Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

See full Lixisenatide Injection drug information
Keep checking

Other Drugs & Atkins Diet

Browse every other medication we’ve checked against Atkins Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
85Minor
2,744No known interaction
85 Minor 2,744 No interaction
Minor

85 interactions

Showing 60 of 85 minor interactions — see all 85 on the Atkins Diet page.

No interaction 2,744 drugs checked — show the list

We also checked Atkins Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Atkins Diet list.

See the full Atkins Diet interactions page
See every supplement checked against Lixisenatide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Atkins Diet monograph › Uses, safety, and every drug interaction in one place Lixisenatide supplement interactions › Every supplement checked against Lixisenatide, ranked by severity Lixisenatide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Following Atkins Diet While Taking Lixisenatide: Common Questions

Can you follow Atkins Diet while taking Lixisenatide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Atkins Diet and Lixisenatide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.