Medication interaction hub

What Supplements Interact with Lixisenatide?

Lixisenatide brand name: Adlyxin. Every interaction below applies to the brands too.

239 Interactions 1 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lixisenatide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lixisenatide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds of hypoglycemia. The one to learn first is Siberian cocklebur, which has caused severe low blood sugar in people, starting soon after it is consumed and often worsening from there.

A smaller group works in the opposite direction. Niacin and ephedra tend to raise glucose and blunt what lixisenatide is doing, so an unexplained climb on your meter deserves the same attention as a crash. Either way, checking more often is the sensible response. Of the 239 ingredients on file, only cocklebur rates major, with 208 moderate and 30 minor.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 208 Minor 30 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lixisenatide: Top Interactions at a Glance

The Lixisenatide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lixisenatide Combinations Today

The Lixisenatide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Cola Nut + Lixisenatidei

Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Rhodiola + Lixisenatidei

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible L-arginine + Lixisenatidei

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Oats + Lixisenatidei

Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Unlikely Kudzu + Lixisenatidei

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Bay Leaf + Lixisenatidei

Concomitant use of bay leaf with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Lixisenatide

All 1,452 ingredients in our database, ranked by severity — 239 with a Lixisenatide interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lixisenatide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cola Nut with Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking cola nut with antidiabetes drugs might interfere with blood glucose control.

Full Cola Nut + Lixisenatide answer

Can you take Rhodiola with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.

Full Rhodiola + Lixisenatide answer

Can you take L-arginine with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.

Full L-arginine + Lixisenatide answer

Can you take Oats with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.

Full Oats + Lixisenatide answer

Can you take Kudzu with Lixisenatide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Full Kudzu + Lixisenatide answer

Can you take Agaricus Mushroom with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agaricus Mushroom + Lixisenatide answer

Can you take Agmatine with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Agmatine + Lixisenatide answer

Can you take Agrimony with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agrimony + Lixisenatide answer

Can you take Alfalfa with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Alfalfa + Lixisenatide answer

Can you take Algal Oil with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.

Full Algal Oil + Lixisenatide answer

Can you take Aloe with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Aloe + Lixisenatide answer

Can you take Ambrette with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ambrette + Lixisenatide answer

Can you take Anise with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Anise + Lixisenatide answer

Can you take Annatto with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal studies suggest that certain annatto extracts may have hypoglycemic or hyperglycemic effects.

Full Annatto + Lixisenatide answer

Can you take Apple with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.

Full Apple + Lixisenatide answer

Can you take Arabinoxylan with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.

Full Arabinoxylan + Lixisenatide answer

Can you take Artemisia Herba-alba with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might increase the risk of hypoglycemia.

Full Artemisia Herba-alba + Lixisenatide answer

Can you take Artichoke with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Artichoke + Lixisenatide answer

Can you take Ash with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Full Ash + Lixisenatide answer

Can you take Ashwagandha with Lixisenatide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ashwagandha + Lixisenatide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lixisenatide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lixisenatide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lixisenatide sits in 1 interaction category. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Lixisenatide through this category.

About Lixisenatide

Lixisenatide is a prescription medication also sold under the brand name Adlyxin. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Lixisenatide  ·  Brand name: Adlyxin.

See the full Lixisenatide Injection drug information

Related: does Lixisenatide deplete any nutrients?

Lixisenatide has 1 reported nutrient association in the research literature — see the Lixisenatide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lixisenatide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lixisenatide.

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Pharmacist Counseling Corner

Lixisenatide & Supplements: Common Questions

What supplements interact with Lixisenatide?
More than you might expect — 239 in total, though they are far from equal: 1 are rated major, 208 moderate, and 30 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, American Ginseng, Astragalus.
Which Lixisenatide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Lixisenatide?
Usually yes — most people on Lixisenatide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Adlyxin have the same supplement interactions as Lixisenatide?
Yes — Adlyxin all contain Lixisenatide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lixisenatide deplete any vitamins or nutrients?
It might — Lixisenatide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lixisenatide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lixisenatide and my other medications?
This page covers Lixisenatide against supplements and herbal ingredients. Checking Lixisenatide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lixisenatide Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.