American Chestnut + Lixisenatide
Lixisenatide brand name: Adlyxin.
We found no known interaction between American Chestnut and Lixisenatide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
American Chestnut and Lixisenatide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lixisenatide and American Chestnut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for American Chestnut at all — not against Lixisenatide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
American Chestnut safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Lixisenatide
This page covers American Chestnut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lixisenatide page lists 239 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).
By severity: 1 major · 208 moderate · 30 minor.
From our pharmacist’s overview on the Lixisenatide page
“Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds…”
Reviewed by 2 · Jul 18, 2026
Taking American Chestnut as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4 real supplement products containing American Chestnut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides American Chestnut. Even though American Chestnut itself has no known interaction with Lixisenatide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where American Chestnut and Lixisenatide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,173 of 1,452 supplements looked up here in the last 7 days
#2,501 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Chestnut is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Chestnut reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Chestnut and Lixisenatide records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About American Chestnut
What is American Chestnut?
- Cough and whooping cough
- Respiratory ailments
- Sore throat (topical/gargle)
- Astringent for mucous membranes
- Traditional tonic and sedative
American chestnut leaves and bark have a long history of folk use for coughs and respiratory complaints, mainly because of their tannin content, which has an astringent effect. However, there is very little modern scientific evidence to support these uses, and safety has not been well studied, so it should be used cautiously and discussed with a healthcare professional.
Castanea dentata · Fagaceae · Leaves and bark · Tea, liquid extract, dried leaf
An interaction check asks whether these two react with each other — it does not ask whether American Chestnut is a good idea for someone in your situation. Here is what our American Chestnut record says about it on its own.
American Chestnut: dosing
There is no standardized or well-established dose for American chestnut. Traditional use involved teas or extracts made from the dried leaves, but the amount of active compounds can vary widely depending on the product and how it is prepared.If you choose to use a product, follow the directions on the label and do not exceed them.
From our American Chestnut monograph — the full record covers uses, side effects and every documented interaction.
About Lixisenatide Injection
What Is Lixisenatide Injection Used For?
Brand name: Adlyxin
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Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.
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Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
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Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.
Other Drugs & American Chestnut
Browse every other medication we’ve checked against American Chestnut — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked American Chestnut against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Rosuvastatin ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Ibuprofen ›
- Tirzepatide ›
- Docusate ›
- Methamphetamine ›
- Warfarin Sodium ›
- Sumatriptan ›
- Tadalafil ›
- Valacyclovir ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Propranolol ›
- Metformin ›
- Isotretinoin ›
- Lisdexamfetamine ›
- Methotrexate ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Doxycycline ›
- Acyclovir ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Lamotrigine ›
- Levothyroxine, Liothyronine ›
- Dextroamphetamine ›
- Quetiapine ›
- Naproxen ›
- Clonazepam ›
- Acetaminophen, Codeine ›
- Omeprazole ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Duloxetine ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full American Chestnut list.
American Chestnut References
The 2 sources that drive our American Chestnut monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Chestnut is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Lixisenatide Is Linked to Lower Levels of One Nutrient
Natural Medicines records Lixisenatide as a medicine that can lower these. This is not an interaction with American Chestnut — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Lixisenatide nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking American Chestnut and Lixisenatide Together: Common Questions
Is it safe to take American Chestnut with Lixisenatide?
Does Lixisenatide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Lixisenatide and American Chestnut?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.