Drug & supplement interaction

Blue Flag + Lixisenatide

Lixisenatide brand name: Adlyxin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Blue Flag and Lixisenatide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Blue Flag and Lixisenatide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lixisenatide and Blue Flag in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Blue Flag safety at a glance

Blue Flag overall Use caution The root, especially when fresh, can cause nausea, vomiting, and irritation, so it should be used cautiously.
Pregnancy Avoid Avoid during pregnancy because of potential toxicity and lack of safety data.
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lixisenatide and Blue Flag? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lixisenatide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lixisenatide is filed under a single classification — antidiabetes drugs. Blue Flag has documented interactions with 3 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and warfarin (coumadin) (moderate) — and none of Lixisenatide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Blue Flag Does Interact With Other Medications

Blue Flag has 1 major, 77 moderate known drug interactions in our database — Lixisenatide isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 77 No known interaction 2,752 (incl. Lixisenatide)
Taking anything else?

Check Another of Your Medications Against Blue Flag

Covers the 2,830 medications we’ve checked against Blue Flag. Pick one to open its full report.

What to actually watch for

What Blue Flag Itself Has Been Linked To

This is not an interaction — nothing below involves Lixisenatide. It is the side-effect record for Blue Flag on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Blue Flag, this list is the first place to look.

  • Vomiting / Nausea Additional detail

    “Orally, blue flag can cause nausea and vomiting, and the fresh root can irritate mucosa (4,19). Orally and topically, the volatile oil constituent of blue flag irritates mucous membranes and can cause lacrimation, eye inflammation, irritation of the throat, and headache (4).”

    Blue Flag · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

    “Orally, blue flag can cause nausea and vomiting and the fresh blue flag root can irritate mucosa (4,19). The volatile oil constituent of blue flag irritates mucous membranes and can cause irritation of the throat (4).”

    Blue Flag · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  • Headache Additional detail

    “Orally, the volatile oil constituent of blue flag can cause headache (4).”

    Blue Flag · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Everything above comes from the Natural Medicines adverse-effect record for Blue Flag — expand a row for the licensed statement it rests on. We haven’t matched Lixisenatide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Lixisenatide.

Special populations

Blue Flag in Pregnancy & Breastfeeding

Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Lixisenatide

This page covers Blue Flag only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lixisenatide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Lixisenatide page

“Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds…”

Reviewed by 2 · Jul 18, 2026

Open the Lixisenatide interaction page

One more smart check

Taking Blue Flag as Part of a Dietary Supplement Product? Check It for Interactions

We hold 101 real supplement products containing Blue Flag, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Blue Flag. Even though Blue Flag itself has no known interaction with Lixisenatide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Blue Flag and Lixisenatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blue Flag
Top half

#455 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lixisenatide
Steady interest

#1,920 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Blue Flag reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Blue Flag and Lixisenatide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Blue Flag

What is Blue Flag?

  • Skin conditions like acne and eczema
  • Constipation and digestive complaints
  • Liver and gallbladder support (traditional)
  • Lymphatic and 'detox' tonic (traditional)
  • Thyroid and glandular swelling (traditional)

Blue Flag is a flowering plant whose root has been used in traditional and herbal medicine for skin and digestive complaints, but there is very little modern scientific evidence to support these uses. The fresh root can be toxic and irritating, so it should be used cautiously, if at all, and avoided in pregnancy and breastfeeding. Talk to a pharmacist or doctor before trying it.

Iris versicolor · Iridaceae · Dried rhizome (root) · Dried root, tincture, liquid extract, capsules, occasionally in topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Blue Flag is a good idea for someone in your situation. Here is what our Blue Flag record says about it on its own.

Blue Flag: dosing

There is no well-established or standardized dose for Blue Flag, and reliable dosing information from quality clinical research is lacking. Traditional sources used small amounts of the dried root or tincture, but these are not validated by modern studies.If a product is used, follow the directions on the label and start low.

From our Blue Flag monograph — the full record covers uses, side effects and every documented interaction.

Read the full Blue Flag monograph & all interactions
Medication

About Lixisenatide Injection

What Is Lixisenatide Injection Used For?

Brand name: Adlyxin

  • Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

See full Lixisenatide Injection drug information
Keep checking

Other Drugs & Blue Flag

Browse every other medication we’ve checked against Blue Flag — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
77Moderate
0Minor
2,751No known interaction
1 Major 77 Moderate 2,751 No interaction
Major

1 interaction

Moderate

77 interactions

Showing 60 of 77 moderate interactions — see all 77 on the Blue Flag page.

No interaction 2,751 drugs checked — show the list

We also checked Blue Flag against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,751 medications checked with no known interaction — see the full Blue Flag list.

See the full Blue Flag interactions page
See every supplement checked against Lixisenatide, ranked by severity
Evidence & sources

Blue Flag References

The 3 references that drive our Blue Flag monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Blue Flag and Lixisenatide Together: Common Questions

Is it safe to take Blue Flag with Lixisenatide?
We do not list a known interaction between Blue Flag and Lixisenatide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Blue Flag and Lixisenatide combination checked?
Interactions in our licensed database are recorded against drug classes. Lixisenatide is filed under 1 classification, and Blue Flag has documented interactions with 3 drug classes — none of Lixisenatide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Blue Flag interact with any other medications?
Yes. Blue Flag has 78 documented drug interactions in our database — Lixisenatide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lixisenatide interact with any supplements?
Yes. Lixisenatide has documented interactions with 239 supplements in our database — Blue Flag is not one of them. The Lixisenatide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Blue Flag monograph Uses, safety profile, and every drug interaction in one place Lixisenatide Injection drug information The full plain-English guide to this medication Lixisenatide supplement interactions Every supplement checked against Lixisenatide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lixisenatide and Blue Flag?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.