Drug & supplement interaction

Perillyl Alcohol + Lixisenatide

Lixisenatide brand name: Adlyxin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Perillyl Alcohol and Lixisenatide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Perillyl Alcohol and Lixisenatide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lixisenatide and Perillyl Alcohol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Perillyl Alcohol at all — not against Lixisenatide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Perillyl Alcohol safety at a glance

Perillyl Alcohol overall Use caution It is mostly an investigational compound with limited human safety data outside clinical trials.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lixisenatide and Perillyl Alcohol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Perillyl Alcohol Itself Has Been Linked To

This is not an interaction — nothing below involves Lixisenatide. It is the side-effect record for Perillyl Alcohol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Perillyl Alcohol, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Low potassium Worth acting on Additional detail

    “Orally, perillyl alcohol can cause adverse effects including gastrointestinal upset, reflux, nausea, diarrhea or constipation, fatigue, and headache. In high doses, perillyl alcohol has been associated with single reports of acute pancreatitis, increased bilirubin, increased white blood cell count, and hypokalemia.

    Topically, perillyl alcohol has been rarely reported to cause a mild rash or tenderness.”

    Perillyl Alcohol · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 15274. Bailey HH, Wilding G, Tutsch KD, et al. A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. Cancer Chemother Pharmacol 2004;54:368-76. PubMed
    2. 15277. Stearns V, Coop A, Singh B, et al. A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. Clin Cancer Res 2004;10:7583-91. PubMed
    3. 15279. Morgan-Meadows S, Dubey S, Gould M, et al. Phase I trial of perillyl alcohol administered four times daily continuously. Cancer Chemother Pharmacol 2003;52:361-6. PubMed
    4. 15284. Liu G, Oettel K, Bailey H, et al. Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. Invest New Drugs 2003;21:367-72. PubMed
    5. 58047. Ripple, G. H., Gould, M. N., Arzoomanian, R. Z., Alberti, D., Feierabend, C., Simon, K., Binger, K., Tutsch, K. D., Pomplun, M., Wahamaki, A., Marnocha, R., Wilding, G., and Bailey, H. H. Phase I clinical and pharmacokinetic study of perillyl alcohol adm
    6. 58132. Ripple GH, Gould MN, Stewart JA, and et al. Phase I clinical trial of perillyl alcohol administered daily. Clin Cancer Res 1998;4(5):1159-1164.

    “Use of high doses of perillyl alcohol orally can cause potassium depletion leading to hypokalemia.”

    Perillyl Alcohol · Natural Medicines adverse-effect record, reported in hypokalemia.

    3 sources cited
    1. 15284. Liu G, Oettel K, Bailey H, et al. Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. Invest New Drugs 2003;21:367-72. PubMed
    2. 16284. Granath J, Ingvarsson S, von Thiele U, Lundberg U. Stress management: a randomized study of cognitive behavioural therapy and yoga. Cogn Behav Ther 2006;35:3-10. PubMed
    3. 68708. Hudes, G. R., Szarka, C. E., Adams, A., Ranganathan, S., McCauley, R. A., Weiner, L. M., Langer, C. J., Litwin, S., Yeslow, G., Halberr, T., Qian, M., and Gallo, J. M. Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refract
  • Pancreatitis Worth acting on Additional detail

    “Orally, perillyl alcohol can cause gastrointestinal upset, reflux, nausea, vomiting, lack of appetite, bloating, belting, heartburn, diarrhea, or constipation. Some side effects appear to be dose related. Higher doses are more likely to cause gastrointestinal upset such as reflux.”

    Perillyl Alcohol · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 15274. Bailey HH, Wilding G, Tutsch KD, et al. A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. Cancer Chemother Pharmacol 2004;54:368-76. PubMed
    2. 15277. Stearns V, Coop A, Singh B, et al. A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. Clin Cancer Res 2004;10:7583-91. PubMed
    3. 15279. Morgan-Meadows S, Dubey S, Gould M, et al. Phase I trial of perillyl alcohol administered four times daily continuously. Cancer Chemother Pharmacol 2003;52:361-6. PubMed
    4. 15284. Liu G, Oettel K, Bailey H, et al. Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. Invest New Drugs 2003;21:367-72. PubMed
    5. 58047. Ripple, G. H., Gould, M. N., Arzoomanian, R. Z., Alberti, D., Feierabend, C., Simon, K., Binger, K., Tutsch, K. D., Pomplun, M., Wahamaki, A., Marnocha, R., Wilding, G., and Bailey, H. H. Phase I clinical and pharmacokinetic study of perillyl alcohol adm
    6. 58132. Ripple GH, Gould MN, Stewart JA, and et al. Phase I clinical trial of perillyl alcohol administered daily. Clin Cancer Res 1998;4(5):1159-1164.
  • Yellowing of the skin or eyes Worth acting on Additional detail

    Recorded for Perillyl Alcohol in the same Natural Medicines adverse-effect record shown under Low potassium above.

  • Heartburn / Stomach upset / Constipation Additional detail

    Recorded for Perillyl Alcohol in the same Natural Medicines adverse-effect record shown under Low potassium above.

  • Bloating or gas / Reduced appetite Additional detail

    Recorded for Perillyl Alcohol in the same Natural Medicines adverse-effect record shown under Pancreatitis above.

  • A stuffy or runny nose / Itching Additional detail

    “Intranasally, perillyl alcohol has been associated with nasal soreness or itching, runny nose, and skin irritation.”

    Perillyl Alcohol · Natural Medicines adverse-effect record, reported in skin irritation.

    1 source cited
    1. 106535. Schönthal AH, Peereboom DM, Wagle N, et al. Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma. Neurooncol Adv 2021;3(1):vdab005. PubMed

Showing the 10 most notable of 16 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Perillyl Alcohol — expand a row for the licensed statement it rests on. We haven’t matched Lixisenatide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Lixisenatide.

Everything else you take

See Every Supplement That Interacts With Lixisenatide

This page covers Perillyl Alcohol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lixisenatide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Lixisenatide page

“Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds…”

Reviewed by 2 · Jul 18, 2026

Open the Lixisenatide interaction page

How much people look this up

Where Perillyl Alcohol and Lixisenatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Perillyl Alcohol
Steady interest

#1,210 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lixisenatide
Steady interest

#2,355 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Perillyl Alcohol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Perillyl Alcohol and Lixisenatide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Perillyl Alcohol

What is Perillyl Alcohol?

  • Cancer research (investigational)
  • Antioxidant interest
  • General wellness supplement
  • Aromatherapy-related products

Perillyl alcohol is a natural compound found in the essential oils of plants like mint, lavender, and citrus, and it has mainly been studied as an experimental anti-cancer agent rather than as an everyday supplement. The evidence in people is limited and still under investigation, so it should not be used to treat or prevent any disease without medical supervision. Talk to your pharmacist or doctor before trying it.

Naturally found in the essential oils of plants such as lavender, peppermint, sage, cherries, and citrus fruits; often produced from limonene · Capsules, oral liquid, and (in research settings) intranasal preparations

An interaction check asks whether these two react with each other — it does not ask whether Perillyl Alcohol is a good idea for someone in your situation. Here is what our Perillyl Alcohol record says about it on its own.

Perillyl Alcohol: dosing

There is no established standard supplement dose of perillyl alcohol for the general public. The doses used in research were chosen for clinical trials and were given under close medical supervision, so they do not apply to over-the-counter use.If you choose to use a product that contains perillyl alcohol, follow the directions on the product label and do not exceed them.

From our Perillyl Alcohol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Perillyl Alcohol monograph & all interactions
Medication

About Lixisenatide Injection

What Is Lixisenatide Injection Used For?

Brand name: Adlyxin

  • Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

See full Lixisenatide Injection drug information
Keep checking

Other Drugs & Perillyl Alcohol

Browse every other medication we’ve checked against Perillyl Alcohol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Perillyl Alcohol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Perillyl Alcohol list.

See the full Perillyl Alcohol interactions page
See every supplement checked against Lixisenatide, ranked by severity
Evidence & sources

Perillyl Alcohol References

The 18 references that drive our Perillyl Alcohol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bailey HH, Wilding G, Tutsch KD, et al. A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. Cancer Chemother Pharmacol 2004;54:368-76. PubMed
  2. Stearns V, Coop A, Singh B, et al. A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia. Clin Cancer Res 2004;10:7583-91. PubMed
  3. Morgan-Meadows S, Dubey S, Gould M, et al. Phase I trial of perillyl alcohol administered four times daily continuously. Cancer Chemother Pharmacol 2003;52:361-6. PubMed
  4. Liu G, Oettel K, Bailey H, et al. Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. Invest New Drugs 2003;21:367-72. PubMed
  5. Granath J, Ingvarsson S, von Thiele U, Lundberg U. Stress management: a randomized study of cognitive behavioural therapy and yoga. Cogn Behav Ther 2006;35:3-10. PubMed
  6. Ripple, G. H., Gould, M. N., Arzoomanian, R. Z., Alberti, D., Feierabend, C., Simon, K., Binger, K., Tutsch, K. D., Pomplun, M., Wahamaki, A., Marnocha, R., Wilding, G., and Bailey, H. H. Phase I clinical and pharmacokinetic study of perillyl alcohol adm
  7. Ripple GH, Gould MN, Stewart JA, and et al. Phase I clinical trial of perillyl alcohol administered daily. Clin Cancer Res 1998;4(5):1159-1164.
  8. Hudes, G. R., Szarka, C. E., Adams, A., Ranganathan, S., McCauley, R. A., Weiner, L. M., Langer, C. J., Litwin, S., Yeslow, G., Halberr, T., Qian, M., and Gallo, J. M. Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refract
  9. Bailey, H. H., Levy, D., Harris, L. S., Schink, J. C., Foss, F., Beatty, P., and Wadler, S. A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96. Gynecol.Oncol. 2002;85(3):464- PubMed
  10. Murren, J. R., Pizzorno, G., DiStasio, S. A., McKeon, A., Peccerillo, K., Gollerkari, A., McMurray, W., Burtness, B. A., Rutherford, T., Li, X., Ho, P. T., and Sartorelli, A. Phase I study of perillyl alcohol in patients with refractory malignancies. Canc PubMed
  11. Azzoli, C. G., Miller, V. A., Ng, K. K., Krug, L. M., Spriggs, D. R., Tong, W. P., Riedel, E. R., and Kris, M. G. A phase I trial of perillyl alcohol in patients with advanced solid tumors. Cancer Chemother.Pharmacol. 2003;51(6):493-498. PubMed
  12. Meadows, S. M., Mulkerin, D., Berlin, J., Bailey, H., Kolesar, J., Warren, D., and Thomas, J. P. Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer. Int J Gastrointest.Cancer 2002;32(2-3):125-128. PubMed
  13. Stratton SP, Alberts DS, Einspahr JG, et al. A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. Cancer Prev Res (Phila). 2010;3(2):160-9. PubMed
  14. da Fonseca CO, Linden R, Futuro D, Gattass CR, Quirico-Santos T. Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. Arch Immunol Ther Exp (Warsz). 2008;56(4):267-76. PubMed
  15. Stratton SP, Saboda KL, Myrdal PB, et al. Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer. Nutr Cancer. 2008;60(3):325-30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Perillyl Alcohol and Lixisenatide Together: Common Questions

Is it safe to take Perillyl Alcohol with Lixisenatide?
We do not list a known interaction between Perillyl Alcohol and Lixisenatide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Lixisenatide interact with any supplements?
Yes. Lixisenatide has documented interactions with 239 supplements in our database — Perillyl Alcohol is not one of them. The Lixisenatide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Perillyl Alcohol monograph Uses, safety profile, and every drug interaction in one place Lixisenatide Injection drug information The full plain-English guide to this medication Lixisenatide supplement interactions Every supplement checked against Lixisenatide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lixisenatide and Perillyl Alcohol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.