Drug & supplement interaction

Butcher's Broom + Lixisenatide

Lixisenatide brand name: Adlyxin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Butcher's Broom and Lixisenatide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Butcher's Broom and Lixisenatide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lixisenatide and Butcher's Broom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Butcher's Broom safety at a glance

Butcher's Broom overall Use caution Generally well tolerated short-term in most healthy adults, but evidence on long-term safety is limited.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information exists, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lixisenatide and Butcher's Broom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lixisenatide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lixisenatide is filed under a single classification — antidiabetes drugs. Butcher's Broom has documented interactions with 2 drug classes — the most serious being alpha-adrenergic agonists (moderate) and alpha-adrenergic antagonists (moderate) — and none of Lixisenatide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Butcher's Broom Does Interact With Other Medications

Butcher's Broom has 158 moderate known drug interactions in our database — Lixisenatide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 158 No known interaction 2,672 (incl. Lixisenatide)
Taking anything else?

Check Another of Your Medications Against Butcher's Broom

Covers the 2,830 medications we’ve checked against Butcher's Broom. Pick one to open its full report.

What to actually watch for

What Butcher's Broom Itself Has Been Linked To

This is not an interaction — nothing below involves Lixisenatide. It is the side-effect record for Butcher's Broom on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Butcher's Broom, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Dehydration / High potassium Worth acting on Additional detail

    “Orally, butcher's broom may cause nausea, vomiting, diarrhea, dyspepsia, heartburn, and gastritis. A 39-year-old female with poorly-controlled diabetes reported severe vomiting and diarrhea after taking butcher's broom for 5 days and was ultimately hospitalized with dehydration, hyperkalemia, acidosis, and sinus tachycardia.”

    Butcher's Broom · Natural Medicines adverse-effect record, reported in diabetes.

    4 sources cited
    1. 10068. Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology 2000;51:535-44.. PubMed
    2. 37494. Cluzan, R. V., Alliot, F., Ghabboun, S., and Pascot, M. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology 1996;29(1):29-35.
    3. 37498. Parrado F, Buzzi A. A study of the efficacy and tolerability of a preparation containing Ruscus aculeatus in the treatment of chronic venous insufficiency of the lower limbs. Clin Drug Invest 1999;18(4):255-61. DOI
    4. 94778. Sadarmin PP, Timperley J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J Emerg Med 2013;45(3):e63-e65. PubMed
  • Heartburn / Stomach upset / Diarrhea / Vomiting / Nausea Additional detail

    “Orally, butcher's broom seems to be well tolerated, short-term.

    Most Common Adverse Effects:

    Orally: Diarrhea, dyspepsia, gastritis, heartburn, nausea, and vomiting.

    Topically: Contact dermatitis in sensitive individuals.”

    Butcher's Broom · Natural Medicines adverse-effect record, reported in dermatitis.

  • A fast or pounding heartbeat Additional detail

    Recorded for Butcher's Broom in the same Natural Medicines adverse-effect record shown under Dehydration / High potassium above.

  • A skin rash Additional detail

    “Topically, butcher's broom may cause contact dermatitis. A 30-year-old female developed an erythematous, papular, pruritic rash on both legs after applying a cream containing butcher's broom root extract (Fabroven, Pierre Fabre Iberica) to varicose veins for 2 months. The rash spread to the entire body, and the patient had positive patch tests to ethanol extracts of butcher's broom.”

    Butcher's Broom · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 37487. Landa, N., Aguirre, A., Goday, J., Raton, J. A., and Diaz-Perez, J. L. Allergic contact dermatitis from a vasoconstrictor cream. Contact Dermatitis 1990;22(5):290-291. PubMed
    2. 94780. Ramirez-Hernandez M, Garcia-Selles J, Merida-Fernandez C, Martinez-Escribano JA. Allergic contact dermatitis to ruscogenins. Contact Dermatitis 2006;54(1):60. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Butcher's Broom — expand a row for the licensed statement it rests on. We haven’t matched Lixisenatide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Lixisenatide.

Everything else you take

See Every Supplement That Interacts With Lixisenatide

This page covers Butcher's Broom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lixisenatide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Lixisenatide page

“Lixisenatide (Adlyxin) is injected to lower blood sugar in type 2 diabetes, and nearly everything on this page acts on blood sugar too, which is why I would treat the list with genuine care rather than a shrug. Most of the entries, from bitter melon and fenugreek to both types of ginseng, can push glucose lower still and raise the odds…”

Reviewed by 2 · Jul 18, 2026

Open the Lixisenatide interaction page

One more smart check

Taking Butcher's Broom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 439 real supplement products containing Butcher's Broom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butcher's Broom. Even though Butcher's Broom itself has no known interaction with Lixisenatide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Butcher's Broom and Lixisenatide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Butcher's Broom
Top 25%

#360 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lixisenatide
Steady interest

#1,907 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Butcher's Broom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Butcher's Broom and Lixisenatide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Butcher's Broom

What is Butcher's Broom?

Butcher's Broom
  • Chronic venous insufficiency
  • Varicose veins
  • Leg swelling and heaviness
  • Hemorrhoids
  • Circulation problems

Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence suggests it may help reduce swelling and discomfort. Quality and dosing vary widely between products, and it should not replace proven treatments. Talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have a health condition.

Ruscus aculeatus · Asparagaceae · Rhizome (underground stem) and roots · Capsules, tablets, extracts, teas, and topical creams or ointments

An interaction check asks whether these two react with each other — it does not ask whether Butcher's Broom is a good idea for someone in your situation. Here is what our Butcher's Broom record says about it on its own.

Butcher's Broom: dosing

There is no single official or standardized dose of butcher's broom. Products vary widely in their strength, how they are made, and whether they include other ingredients, which makes it hard to compare them.Many extracts are standardized to a certain amount of ruscogenins, but the right amount depends on the specific product.

From our Butcher's Broom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Butcher's Broom monograph & all interactions
Medication

About Lixisenatide Injection

What Is Lixisenatide Injection Used For?

Brand name: Adlyxin

  • Lixisenatide injection is used along with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Lixisenatide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used instead of insulin to treat people with diabetes who need insulin. Lixisenatide injection is in a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Lixisenatide injection also slows the emptying of the stomach and causes a decrease in appetite.

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lixisenatide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

See full Lixisenatide Injection drug information
Keep checking

Other Drugs & Butcher's Broom

Browse every other medication we’ve checked against Butcher's Broom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
158Moderate
0Minor
2,671No known interaction
158 Moderate 2,671 No interaction
Moderate

158 interactions

Showing 60 of 158 moderate interactions — see all 158 on the Butcher's Broom page.

No interaction 2,671 drugs checked — show the list

We also checked Butcher's Broom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,671 medications checked with no known interaction — see the full Butcher's Broom list.

See the full Butcher's Broom interactions page
See every supplement checked against Lixisenatide, ranked by severity
Evidence & sources

Butcher's Broom References

The 8 references that drive our Butcher's Broom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology 2000;51:535-44.. PubMed
  2. Redman DA. Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report. J Altern Complement Med 2000;6:539-49..
  3. Landa, N., Aguirre, A., Goday, J., Raton, J. A., and Diaz-Perez, J. L. Allergic contact dermatitis from a vasoconstrictor cream. Contact Dermatitis 1990;22(5):290-291. PubMed
  4. Cluzan, R. V., Alliot, F., Ghabboun, S., and Pascot, M. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology 1996;29(1):29-35.
  5. Parrado F, Buzzi A. A study of the efficacy and tolerability of a preparation containing Ruscus aculeatus in the treatment of chronic venous insufficiency of the lower limbs. Clin Drug Invest 1999;18(4):255-61. DOI
  6. Sadarmin PP, Timperley J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J Emerg Med 2013;45(3):e63-e65. PubMed
  7. Ramirez-Hernandez M, Garcia-Selles J, Merida-Fernandez C, Martinez-Escribano JA. Allergic contact dermatitis to ruscogenins. Contact Dermatitis 2006;54(1):60. PubMed
  8. European Medicines Agency. Assessment report on Ruscus Aculeatus L rhizome. EMEA/HMPC/261939/2007. London, September 4, 2008. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2009/12/WC500018288.pdf. Acces

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Butcher's Broom and Lixisenatide Together: Common Questions

Is it safe to take Butcher's Broom with Lixisenatide?
We do not list a known interaction between Butcher's Broom and Lixisenatide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Butcher's Broom and Lixisenatide combination checked?
Interactions in our licensed database are recorded against drug classes. Lixisenatide is filed under 1 classification, and Butcher's Broom has documented interactions with 2 drug classes — none of Lixisenatide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Butcher's Broom interact with any other medications?
Yes. Butcher's Broom has 158 documented drug interactions in our database — Lixisenatide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lixisenatide interact with any supplements?
Yes. Lixisenatide has documented interactions with 239 supplements in our database — Butcher's Broom is not one of them. The Lixisenatide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Butcher's Broom monograph Uses, safety profile, and every drug interaction in one place Lixisenatide Injection drug information The full plain-English guide to this medication Lixisenatide supplement interactions Every supplement checked against Lixisenatide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lixisenatide and Butcher's Broom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.