Cefuroxime

38 interactions 140 cited references

Also sold as: Ceftin®

About Cefuroxime

Cefuroxime is a cephalosporin antibiotic used to treat bacterial infections including bronchitis, gonorrhea, Lyme disease, and skin and urinary tract infections. Read the full Cefuroxime drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Phosphate Methotrexate Injection Levonorgestrel Intrauterine System Levonorgestrel

36 Major 2 Moderate

All (38) Major (36) Moderate (2)

Major

Cefuroxime Aluminum Carbonate, Basic Decreased cefuroxime axetil exposure Details Cefuroxime Aluminum Hydroxide AlternaGEL® Decreased cefuroxime axetil exposure Details Cefuroxime Aluminum Phosphate Decreased cefuroxime axetil exposure Details Cefuroxime Calcium Carbonate Alka-Mints Decreased cefuroxime axetil exposure Details Cefuroxime Calcium Silicate Decreased cefuroxime axetil exposure Details Cefuroxime Cimetidine Tagamet Decreased cefuroxime axetil exposure Details Cefuroxime Dexlansoprazole Dexilant Decreased cefuroxime axetil exposure Details Cefuroxime Dihydroxyaluminum Aminoacetate Decreased cefuroxime axetil exposure Details Cefuroxime Dihydroxyaluminum Sodium Carbonate Decreased cefuroxime axetil exposure Details Cefuroxime Ebrotidine Decreased cefuroxime axetil exposure Details Cefuroxime Esomeprazole Nexium Decreased cefuroxime axetil exposure Details Cefuroxime Famotidine Calmicid Decreased cefuroxime axetil exposure Details Cefuroxime Lansoprazole Prevacid Decreased cefuroxime axetil exposure Details Cefuroxime Magaldrate Decreased cefuroxime axetil exposure Details Cefuroxime Magnesium Carbonate Decreased cefuroxime axetil exposure Details Cefuroxime Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased cefuroxime axetil exposure Details Cefuroxime Magnesium Oxide Mag-Ox 400 Decreased cefuroxime axetil exposure Details Cefuroxime Magnesium Peroxide Decreased cefuroxime axetil exposure Details Cefuroxime Magnesium Trisilicate Decreased cefuroxime axetil exposure Details Cefuroxime Nizatidine Axid® Decreased cefuroxime axetil exposure Details Cefuroxime Omeprazole Gastrobim Decreased cefuroxime axetil exposure Details Cefuroxime Pantoprazole Protonix Decreased cefuroxime axetil exposure Details Cefuroxime Rabeprazole Aciphex Decreased cefuroxime axetil exposure Details Cefuroxime Ranitidine Decreased cefuroxime axetil exposure Details Cefuroxime Ranitidine Bismuth Citrate Decreased cefuroxime axetil exposure Details Cefuroxime Roxatidine Decreased cefuroxime axetil exposure Details Cefuroxime Sodium Bicarbonate Alka-Seltzer® Heartburn Decreased cefuroxime axetil exposure Details Cefuroxime Estradiol Delestrogen Decreased contraceptive effectiveness Details Cefuroxime Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cefuroxime Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cefuroxime Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefuroxime Furosemide Injection Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefuroxime Levonorgestrel After banger Decreased contraceptive effectiveness Details Cefuroxime Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Cefuroxime Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cefuroxime Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Cefuroxime Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Cefuroxime Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.