Chlorambucil

21 interactions 251 cited references
Also sold as: Leukeran Leukeran®
About Chlorambucil

Chlorambucil is used to treat a certain type of chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (types of cancer that begin in certain white blood cells that normally fight infection). Chlorambucil is in… Read the full Chlorambucil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live
9 Contraindicated 12 Major
All (21) Contraindicated (9) Major (12)

Contraindicated

Chlorambucil Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Chlorambucil Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Chlorambucil Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Chlorambucil Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Chlorambucil Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Chlorambucil Amifampridine Increased risk of seizures Details Chlorambucil Bupropion Aplenzin Increased risk of seizures Details Chlorambucil Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Chlorambucil Clomipramine Anafranil Increased risk of seizures Details Chlorambucil Donepezil Adlarity Reduced seizure threshold Details Chlorambucil Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Hydroxychloroquine Plaquenil An increased risk of seizures Details Chlorambucil Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Chlorambucil Tramadol ConZip An increased risk of seizure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.