Chlorothiazide
71 interactions 5 explained in plain English
Also sold as:
Diuril
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Insulin Detemir (Rdna Origin) Injection
Meloxicam Injection
Nateglinide
Acarbose
Glimepiride
Dulaglutide Injection
Major
Chlorothiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Chlorothiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Chlorothiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Chlorothiazide Acarbose Prandase® Explained An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Chlorothiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Chlorothiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Alogliptin Nesina An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Canagliflozin Invokana An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Chlorothiazide Dapagliflozin Farxiga An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Chlorothiazide Dulaglutide Injection Trulicity An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Exenatide Injection Bydureon An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Chlorothiazide Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Chlorothiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Glimepiride Amaryl An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Glipizide Glucotrol An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Chlorothiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Chlorothiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hyperglycemia and an increased insulin requirement Details Chlorothiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorothiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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