Chlorthalidone
73 interactions 5 explained in plain English
Also sold as:
Hemiclor
Thalitone
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Hydromorphone Rectal
Nateglinide
Meloxicam Injection
Acarbose
Glimepiride
Dulaglutide Injection
Major
Chlorthalidone Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Chlorthalidone Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Chlorthalidone Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Chlorthalidone Acarbose Prandase® Explained An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Chlorthalidone Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Chlorthalidone Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Alogliptin Nesina An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Canagliflozin Invokana An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Chlorthalidone Dapagliflozin Farxiga An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Chlorthalidone Dulaglutide Injection Trulicity An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Exenatide Injection Bydureon An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Chlorthalidone Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Chlorthalidone Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Glimepiride Amaryl An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Glipizide Glucotrol An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Chlorthalidone Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Chlorthalidone Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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