Chlorthalidone

73 interactions 5 explained in plain English
Also sold as: Hemiclor Thalitone
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydromorphone Rectal Nateglinide Meloxicam Injection Acarbose Glimepiride Dulaglutide Injection
55 Major 18 Moderate
All (73) Major (55) Moderate (18)

Moderate

Chlorthalidone Lisinopril Prinivil Explained Reduction of blood pressure Details Chlorthalidone Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Chlorthalidone Benazepril Lotensin Reduction of blood pressure Details Chlorthalidone Calcitriol Rocaltrol Increased serum calcium levels resulting in hypercalcemia Details Chlorthalidone Calcitriol Topical Vectical Increased serum calcium levels resulting in hypercalcemia Details Chlorthalidone Captopril Capoten® Reduction of blood pressure Details Chlorthalidone Cyclophosphamide Cytoxan® Increased risk of myelosuppression Details Chlorthalidone Cyclophosphamide Injection Cytoxan® Injection Increased risk of myelosuppression Details Chlorthalidone Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Chlorthalidone Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Chlorthalidone Enalapril Epaned Reduction of blood pressure Details Chlorthalidone Fosinopril Monopril® Reduction of blood pressure Details Chlorthalidone Hydrocortisone Ala-Cort Hypokalemia Details Chlorthalidone Hydrocortisone Injection A-Hydrocort® Hypokalemia Details Chlorthalidone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Chlorthalidone Moexipril Univasc® Reduction of blood pressure Details Chlorthalidone Olodaterol Oral Inhalation Striverdi An increased risk of ECG changes and/or an increased risk of hypokalemia Details Chlorthalidone Perindopril Aceon Reduction of blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.