Chlorthalidone

73 interactions 5 explained in plain English
Also sold as: Hemiclor Thalitone
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydromorphone Rectal Nateglinide Meloxicam Injection Acarbose Glimepiride Dulaglutide Injection
55 Major 18 Moderate
All (73) Major (55) Moderate (18)

Major

Chlorthalidone Linagliptin Tradjenta An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Liraglutide Injection Saxenda An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Lithium Carbonate Lithobid Increased lithium concentrations and lithium toxicity (weakness, tremor, excessive thirst, confusion) Details Chlorthalidone Lixisenatide Injection Adlyxin® An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Chlorthalidone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Chlorthalidone Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Chlorthalidone Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Chlorthalidone Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Chlorthalidone Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.