Chondroitin and Defibrotide Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Defibrotide Injection
Chondroitin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Elevations of International Normalized Ratio serum values and potentiation of anticoagulant effects
Interaction Deep Dive
Concurrent use of chondroitin sulfate with anticoagulants might increase the risk of bleeding. In a case report, a 69-year-old man developed elevations of his International Normalized Ratio after adding chondroitin sulfate to a stable dose regimen of warfarin1. Chondroitin sulfate is a component of danaparoid; theoretically, chondroitin may increase the anti-factor Xa level. Conversely, no significant hematological changes were noted in a group of patients during six months of oral chondroitin therapy 2, suggesting that there may be no clinically significant effect.
Why it happens (mechanism)
Unknown
Common questions
Can I take Chondroitin and Defibrotide Injection together?
Elevations of International Normalized Ratio serum values and potentiation of anticoagulant effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Chondroitin and Defibrotide Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Chondroitin or Defibrotide Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Rozenfeld V, Crain JL, & Callahan KA: Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health-Syst Pharm 2004; 61:306-307. PubMed
- Oliviero U, Sorrentino GP, De Paola P, et al: Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drugs Exp Clin Res 1991; 17(1):45-51.
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