Defibrotide Injection

87 interactions 157 cited references
Also sold as: Defitelio Defitelio®
About Defibrotide Injection

Defibrotide injection is used to treat adults and children with hepatic veno-occlusive disease (VOD; blocked blood vessels inside the liver, also known as sinusoidal obstruction syndrome), who have kidney or lung problems after receiving a hematopoietic stem-cell transplant (HSCT; procedure in which certain blood cells… Read the full Defibrotide Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Defibrotide Injection Abciximab Increased risk of bleeding Details Defibrotide Injection Acenocoumarol Increased risk of bleeding Details Defibrotide Injection Alteplase, Recombinant Activase Increased risk of bleeding Details Defibrotide Injection Anagrelide Agrylin Increased risk of bleeding Details Defibrotide Injection Anistreplase Increased risk of bleeding Details Defibrotide Injection Apixaban Eliquis Increased risk of bleeding Details Defibrotide Injection Ardeparin Increased risk of bleeding Details Defibrotide Injection Argatroban Increased risk of bleeding Details Defibrotide Injection Aspirin Acuprin® Increased risk of bleeding Details Defibrotide Injection Bemiparin Increased risk of bleeding Details Defibrotide Injection Bivalirudin Angiomax Increased risk of bleeding Details Defibrotide Injection Certoparin Increased risk of bleeding Details Defibrotide Injection Cilostazol Pletal® Increased risk of bleeding Details Defibrotide Injection Clopidogrel Plavix Increased risk of bleeding Details Defibrotide Injection Dabigatran Etexilate Increased risk of bleeding Details Defibrotide Injection Dalteparin Fragmin Increased risk of bleeding Details Defibrotide Injection Danaparoid Increased risk of bleeding Details Defibrotide Injection Desirudin Iprivask Increased risk of bleeding Details Defibrotide Injection Dipyridamole Permole® Increased risk of bleeding Details Defibrotide Injection Edoxaban Savaysa Increased risk of bleeding Details Defibrotide Injection Enoxaparin Lovenox Increased risk of bleeding Details Defibrotide Injection Eptifibatide Increased risk of bleeding Details Defibrotide Injection Fondaparinux Arixtra Increased risk of bleeding Details Defibrotide Injection Heparin Increased risk of bleeding Details Defibrotide Injection Iloprost Aurlumyn Increased risk of bleeding Details Defibrotide Injection Lepirudin Increased risk of bleeding Details Defibrotide Injection Nadroparin Increased risk of bleeding Details Defibrotide Injection Parnaparin Increased risk of bleeding Details Defibrotide Injection Phenindione Increased risk of bleeding Details Defibrotide Injection Phenprocoumon Increased risk of bleeding Details Defibrotide Injection Prasugrel Effient Increased risk of bleeding Details Defibrotide Injection Protein C Ceprotin Increased risk of bleeding Details Defibrotide Injection Reteplase, Recombinant Increased risk of bleeding Details Defibrotide Injection Reviparin Increased risk of bleeding Details Defibrotide Injection Rivaroxaban Xarelto Increased risk of bleeding Details Defibrotide Injection Streptokinase Increased risk of bleeding Details Defibrotide Injection Sulfinpyrazone Increased risk of bleeding Details Defibrotide Injection Tenecteplase Increased risk of bleeding Details Defibrotide Injection Ticagrelor Brilinta Increased risk of bleeding Details Defibrotide Injection Ticlopidine Ticlid® Increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.