Cilostazol

78 interactions 8 explained in plain English
Also sold as: Pletal®
About Cilostazol

Cilostazol is an antiplatelet medication used to reduce leg pain caused by poor blood flow during walking. Read the full Cilostazol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Defibrotide Injection Miconazole Vaginal Abametapir Nifedipine Aspirin
2 Contraindicated 65 Major 11 Moderate
All (78) Contraindicated (2) Major (65) Moderate (11)

Major

Cilostazol Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Cilostazol Ibrutinib Imbruvica Increased risk of bleeding Details Cilostazol Ibuprofen Addaprin An increased risk of bleeding Details Cilostazol Ketoconazole Topical Extina® Foam Increased cilostazol exposure and an altered (increased/reduced) cilostazol active metabolites exposure Details Cilostazol Ketoprofen Actron® An increased risk of bleeding Details Cilostazol Ketorolac Acular An increased risk of bleeding Details Cilostazol Ketorolac Injection Acular An increased risk of bleeding Details Cilostazol Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Cilostazol Ketorolac Ophthalmic Acular An increased risk of bleeding Details Cilostazol Lansoprazole Prevacid Increased cilostazol exposure Details Cilostazol Letermovir Injection Prevymis Increased cilostazol exposure Details Cilostazol Letrozole Femara Increased cilostazol exposure Details Cilostazol Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Cilostazol Meclofenamate Meclodium® An increased risk of bleeding Details Cilostazol Mefenamic Acid Ponstel® An increased risk of bleeding Details Cilostazol Meloxicam Alloxate An increased risk of bleeding Details Cilostazol Meloxicam Injection Alloxate An increased risk of bleeding Details Cilostazol Melphalan Alkeran An increased risk of bleeding Details Cilostazol Melphalan Injection Alkeran An increased risk of bleeding Details Cilostazol Methylergonovine Methergine Increased methylergonovine exposure Details Cilostazol Miconazole Buccal Oravig Increased cilostazol exposure Details Cilostazol Miconazole Topical Aloe Vesta Antifungal Increased cilostazol exposure Details Cilostazol Miconazole Vaginal Lagicam Increased cilostazol exposure Details Cilostazol Miconazole Aloe Vesta Antifungal Increased cilostazol exposure Details Cilostazol Nabumetone Relafen An increased risk of bleeding Details Cilostazol Naproxen Aleve An increased risk of bleeding Details Cilostazol Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Cilostazol Simvastatin Flolipid Explained Increased simvastatin exposure Details Cilostazol Capsaicin Arthricare for Women Moisturizing Increased risk of bleeding Details Cilostazol Capsaicin Topical Aspercreme Warming® Increased risk of bleeding Details Cilostazol Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of bleeding Details Cilostazol Dofetilide Tikosyn Increased dofetilide exposure Details Cilostazol Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cilostazol Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cilostazol Ibritumomab Injection Zevalin® An increased risk of bleeding and hemorrhage Details Cilostazol Icosapent Ethyl Vascepa An increased risk of bleeding Details Cilostazol Iloprost Aurlumyn Increased risk of bleeding Details Cilostazol Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities or intracerebral hemorrhage Details

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