Cinacalcet

Name: Cinacalcet Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Brexpiprazole Doxorubicin Ketoconazole Topical Letermovir Injection Nebivolol

6 Major 2 Moderate

All (8) Major (6) Moderate (2)

Major

Cinacalcet Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Cinacalcet Brexpiprazole Rexulti Increased brexpiprazole exposure Details Cinacalcet Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Cinacalcet Ketoconazole Topical Extina® Foam Increased cinacalcet exposure and an increased risk of cinacalcet-related adverse reactions Details Cinacalcet Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Cinacalcet Nebivolol Bystolic Increased exposure to nebivolol Details

Moderate

Cinacalcet Amitriptyline Elavil Explained Increased exposure of amitriptyline Details Cinacalcet Flecainide Tambocor® Increased flecainide plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.