Drug Interaction Report

Cinoxacin and Didanosine: Interaction Details

A pharmacist-reviewed analysis of the Cinoxacin and Didanosine interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Didanosine

Videx® Videx® EC
+

Cinoxacin

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

Decreased cinoxacin effectiveness

Interaction Deep Dive

Didanosine may interfere with the gastrointestinal absorption of cinoxacin. Didanosine should be taken at least 2 hours before or 2 hours after cinoxacin administration2.

Why it happens (mechanism)

Decreased cinoxacin gastrointestinal absorption

Literature reports

1 report — tap to read

a) Didanosine pediatric formulation is reconstituted with water and antacids, hence, interferes with absorption of quinolone antibiotics 1. Didanosine chewable/buffered tablets are buffered with calcium carbonate and magnesium oxide 3.

Common questions

Can I take Cinoxacin and Didanosine together?

Decreased cinoxacin effectiveness Always confirm with your pharmacist or prescriber before making any change.

How serious is the Cinoxacin and Didanosine interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Cinoxacin or Didanosine need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Product Information: VIDEX(R) pediatric powder for oral solution, didanosine pediatric powder for oral solution. Bristol-Myers Squibb Company, Princeton, NJ, 2009.
  2. Product Information: Cinobac(R), cinoxacin capsules. Eli Lilly and Company, Indianapolis, IN, 2002.
  3. Product Information: Videx(R), didanosine. Bristol-Myers-Squibb Company, Princeton, NJ, USA, 1999. DailyMed
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Didanosine

Keep reading about Didanosine

All Didanosine interactions (68) Didanosine drug information
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Cinoxacin

Keep reading about Cinoxacin

All Cinoxacin interactions (2)
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Didanosine + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Horsetail Slippery Elm + 12 more
Cinoxacin + Activated Charcoal Apple Asarabacca Beer Grapefruit Siberian Cocklebur Sweet Orange Wine + 131 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.