Didanosine

68 interactions 224 cited references
Also sold as: Videx® Videx® EC
About Didanosine

Didanosine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Didanosine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although didanosine does not cure HIV, it may decrease your ch… Read the full Didanosine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Allopurinol Allopurinol Injection Stavudine Ribavirin Oxypurinol Cabotegravir
5 Contraindicated 14 Major 39 Moderate 10 Minor
All (68) Contraindicated (5) Major (14) Moderate (39) Minor (10)

Contraindicated

Didanosine Allopurinol Aloprim Increased serum concentrations of didanosine Details Didanosine Allopurinol Injection Aloprim Increased serum concentrations of didanosine Details Didanosine Oxypurinol Increased serum concentrations of didanosine Details Didanosine Ribavirin Copegus® Increased risk of didanosine-mediated mitochondrial toxicity, resulting in fatal or nonfatal lactic acidosis, fatal hepatic failur... Details Didanosine Stavudine Zerit® Increased risk of lactic acidosis, hepatotoxicity, peripheral neuropathy, and pancreatitis Details

Major

Didanosine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Didanosine Atazanavir Reyataz Reduced solubility and exposure to atazanavir with the didanosine buffered formulation and reduced didanosine exposure with enteri... Details Didanosine Atidarsagene Autotemcel Lenmeldy Interference with the manufacturing of atidarsagene autotemcel Details Didanosine Ciprofloxacin Reduced ciprofloxacin exposure Details Didanosine Cobicistat Tybost Increased risk of adverse effects Details Didanosine Darunavir Increased adverse effects Details Didanosine Etuvetidigene Autotemcel An increased risk of interference with the manufacturing of etuvetidigene autotemcel Details Didanosine Hydroxyurea Droxia An increased risk of peripheral neuropathy, fatal pancreatitis and hepatotoxicity Details Didanosine Methadone Diskets Reduced didanosine exposure Details Didanosine Nelfinavir Viracept An increased risk of drug-drug interaction Details Didanosine Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details Didanosine Tacrolimus Astagraf An increased risk of nephrotoxicity Details Didanosine Tenofovir Disoproxil Fumarate Increased didanosine plasma concentrations and risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis, severe lactic acid... Details Didanosine Zalcitabine Neurotoxicity (peripheral neuropathy) Details

Moderate

Didanosine Amprenavir Reduced amprenavir efficacy Details Didanosine Atevirdine Reduced clinical efficacy of atevirdine Details Didanosine Cinoxacin Decreased cinoxacin effectiveness Details Didanosine Delavirdine Rescriptor® Decreased serum levels of both delavirdine and didanosine Details Didanosine Enoxacin Decreased enoxacin effectiveness Details Didanosine Ganciclovir Cytovene® Oral An increased risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis) Details Didanosine Gatifloxacin Zymaxid Decreased gatifloxacin effectiveness Details Didanosine Gemifloxacin Factive Decreased gemifloxacin bioavailability Details Didanosine Grepafloxacin Decreased grepafloxacin effectiveness Details Didanosine Indinavir Decreased bioavailability and therapeutic efficacy of indinavir Details Didanosine Itraconazole Sporanox Decreased itraconazole effectiveness Details Didanosine Ketoconazole Extina Decreased ketoconazole effectiveness Details Didanosine Levofloxacin Levaquin Decreased levofloxacin effectiveness Details Didanosine Lomefloxacin Decreased lomefloxacin effectiveness Details Didanosine Metoclopramide Increased didanosine plasma concentrations Details Didanosine Moxifloxacin Avelox Decreased moxifloxacin effectiveness Details Didanosine Nalidixic Acid Decreased nalidixic acid serum concentrations by buffered didanosine preparations Details Didanosine Nirmatrelvir Inactivation of both drugs Details Didanosine Norfloxacin Decreased norfloxacin serum and urine levels Details Didanosine Ofloxacin Floxin® Decreased ofloxacin bioavailability and potential loss of ofloxacin efficacy Details Didanosine Ranitidine Increased didanosine plasma concentrations and decreased ranitidine plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.