Didanosine and Ranitidine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ranitidine
No brand names on recordDidanosine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased didanosine plasma concentrations and decreased ranitidine plasma concentrations
Interaction Deep Dive
In a drug interaction study of HIV-infected patients (n=12), didanosine AUC and Cmax increased by 14% and 13%, respectively, and ranitidine AUC decreased by 16% when a single 150-mg dose of ranitidine was administered 2 hours before a single 375-mg dose of a buffered formulation of didanosine11. The clinical significance of these pharmacokinetic changes has not been determined. Consider monitoring the patient for didanosine toxicity and reduced ranitidine efficacy when used in combination.
Why it happens (mechanism)
Unknown
Common questions
Can I take Didanosine and Ranitidine together?
Increased didanosine plasma concentrations and decreased ranitidine plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Didanosine and Ranitidine interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Didanosine or Ranitidine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: VIDEX(R) pediatric powder for oral solution, didanosine pediatric powder for oral solution. Bristol-Myers Squibb Company, Princeton, NJ, 2009.
Keep reading about Ranitidine
Keep reading about Didanosine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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