Ranitidine

45 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Nifedipine Doxorubicin Cyclosporine Ophthalmic Fentanyl Transdermal Patch Octreotide Injection
27 Major 12 Moderate 6 Minor
All (45) Major (27) Moderate (12) Minor (6)

Major

Ranitidine Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Ranitidine Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Ranitidine Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine-related toxicity Details Ranitidine Acalabrutinib Calquence Reduced acalabrutinib exposure Details Ranitidine Bedaquiline Sirturo Increased bedaquiline exposure Details Ranitidine Budesonide Entocort Increased budesonide exposure Details Ranitidine Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Ranitidine Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Ranitidine Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Ranitidine Cyclosporine Injection Atopica Increased risk of renal dysfunction and an increased cycloSPORINE exposure Details Ranitidine Cyclosporine Ophthalmic Cequa Increased risk of renal dysfunction and an increased cycloSPORINE exposure Details Ranitidine Dasatinib Phyrago Reduced dasatinib exposure Details Ranitidine Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Ranitidine Erlotinib Tarceva Reduced erlotinib exposure Details Ranitidine Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Ranitidine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ranitidine Gefitinib Iressa Decreased exposure of gefitinib Details Ranitidine Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Ranitidine Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Ranitidine Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Ranitidine Methylergonovine Methergine Increased methylergonovine exposure Details Ranitidine Methylphenidate Adhansia XR® Altered pharmacodynamic and changes in release profile of methylphenidate Details Ranitidine Methylphenidate Transdermal Patch Daytrana Altered pharmacodynamic and changes in release profile of methylphenidate Details Ranitidine Neratinib Nerlynx Decreased neratinib solubility, absorption, and exposure Details Ranitidine Nifedipine Adalat® Increased NIFEdipine exposure Details Ranitidine Octreotide Bynfezia Decreased octreotide bioavailability Details Ranitidine Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Ranitidine Bosutinib Bosulif Reduced bosutinib exposure Details Ranitidine Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Ranitidine Didanosine Videx® Increased didanosine plasma concentrations and decreased ranitidine plasma concentrations Details Ranitidine Dofetilide Tikosyn Increased dofetilide exposure Details Ranitidine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Ranitidine Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Ranitidine Glipizide Glucotrol Increased glipiZIDE exposure Details Ranitidine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Ranitidine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Ranitidine Memantine Namenda Altered plasma levels of memantine and ranitidine Details Ranitidine Midazolam Nasal Spray Nayzilam Increased midazolam bioavailability Details Ranitidine Midazolam Injection Nayzilam Increased midazolam bioavailability Details

Minor

Ranitidine Aspirin Acuprin® Reduced salicylate plasma levels and decreased antiplatelet effect of aspirin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.