Didanosine

Name: Didanosine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

68 interactions 224 cited references

Also sold as: Videx® Videx® EC

About Didanosine

Didanosine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Didanosine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although didanosine does not cure HIV, it may decrease your ch… Read the full Didanosine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Allopurinol Allopurinol Injection Stavudine Ribavirin Oxypurinol Cabotegravir

5 Contraindicated 14 Major 39 Moderate 10 Minor

All (68) Contraindicated (5) Major (14) Moderate (39) Minor (10)

Contraindicated

Didanosine Allopurinol Aloprim Increased serum concentrations of didanosine Details Didanosine Allopurinol Injection Aloprim Increased serum concentrations of didanosine Details Didanosine Oxypurinol Increased serum concentrations of didanosine Details Didanosine Ribavirin Copegus® Increased risk of didanosine-mediated mitochondrial toxicity, resulting in fatal or nonfatal lactic acidosis, fatal hepatic failur... Details Didanosine Stavudine Zerit® Increased risk of lactic acidosis, hepatotoxicity, peripheral neuropathy, and pancreatitis Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.