Didanosine

68 interactions 224 cited references
Also sold as: Videx® Videx® EC
About Didanosine

Didanosine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Didanosine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although didanosine does not cure HIV, it may decrease your ch… Read the full Didanosine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Allopurinol Allopurinol Injection Stavudine Ribavirin Oxypurinol Cabotegravir
5 Contraindicated 14 Major 39 Moderate 10 Minor
All (68) Contraindicated (5) Major (14) Moderate (39) Minor (10)

Major

Didanosine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Didanosine Atazanavir Reyataz Reduced solubility and exposure to atazanavir with the didanosine buffered formulation and reduced didanosine exposure with enteri... Details Didanosine Atidarsagene Autotemcel Lenmeldy Interference with the manufacturing of atidarsagene autotemcel Details Didanosine Ciprofloxacin Reduced ciprofloxacin exposure Details Didanosine Cobicistat Tybost Increased risk of adverse effects Details Didanosine Darunavir Increased adverse effects Details Didanosine Etuvetidigene Autotemcel An increased risk of interference with the manufacturing of etuvetidigene autotemcel Details Didanosine Hydroxyurea Droxia An increased risk of peripheral neuropathy, fatal pancreatitis and hepatotoxicity Details Didanosine Methadone Diskets Reduced didanosine exposure Details Didanosine Nelfinavir Viracept An increased risk of drug-drug interaction Details Didanosine Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details Didanosine Tacrolimus Astagraf An increased risk of nephrotoxicity Details Didanosine Tenofovir Disoproxil Fumarate Increased didanosine plasma concentrations and risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis, severe lactic acid... Details Didanosine Zalcitabine Neurotoxicity (peripheral neuropathy) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.