Didanosine

68 interactions 224 cited references
Also sold as: Videx® Videx® EC
About Didanosine

Didanosine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Didanosine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although didanosine does not cure HIV, it may decrease your ch… Read the full Didanosine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Didanosine Rifabutin Mycobutin Increased didanosine plasma concentrations Details Didanosine Ritonavir Norvir Inactivation of both drugs Details Didanosine Sulfamethoxazole Sustain Reduced sulfamethoxazole exposure Details Didanosine Tipranavir Aptivus Decreased didanosine plasma concentrations Details Didanosine Trimethoprim Primsol Increased didanosine plasma concentrations and potential for increased trimethoprim plasma concentrations Details Didanosine Trovafloxacin Mesylate Decreased trovafloxacin effectiveness Details Didanosine Valganciclovir Valcyte An increased risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis) Details Didanosine Ganciclovir Injection Cytovene® I.V.® An increased risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis) Details Didanosine Ganciclovir Ophthalmic Zirgan An increased risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis) Details Didanosine Gatifloxacin Ophthalmic Zymar® Decreased gatifloxacin effectiveness Details Didanosine Ketoconazole Topical Extina® Foam Decreased ketoconazole effectiveness Details Didanosine Levofloxacin Injection Levaquin Decreased levofloxacin effectiveness Details Didanosine Metoclopramide Injection Gimoti Increased didanosine plasma concentrations Details Didanosine Metoclopramide Nasal Spray Gimoti Increased didanosine plasma concentrations Details Didanosine Moxifloxacin Injection Avelox Decreased moxifloxacin effectiveness Details Didanosine Moxifloxacin Ophthalmic Moxeza® Decreased moxifloxacin effectiveness Details Didanosine Ofloxacin Ophthalmic Ocuflox Decreased ofloxacin bioavailability and potential loss of ofloxacin efficacy Details Didanosine Ofloxacin Otic Floxin® Otic Decreased ofloxacin bioavailability and potential loss of ofloxacin efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.