Cisplatin Injection

39 interactions 816 cited references
Also sold as: Platinol-AQ® Platinol®
About Cisplatin Injection

Cisplatin is used combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. Cisplatin is used alone or in combination with other medications to treat cancer of the ovaries (cancer that begins in the female… Read the full Cisplatin Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Dengue Tetravalent Vaccine, Live
9 Contraindicated 22 Major 8 Moderate
All (39) Contraindicated (9) Major (22) Moderate (8)

Contraindicated

Cisplatin Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Cisplatin Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Cisplatin Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Cisplatin Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Cisplatin Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Cisplatin Injection Doxorubicin Adriamycin Leukemia Details Cisplatin Injection Doxorubicin Hydrochloride Liposome Leukemia Details Cisplatin Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Fosphenytoin Cerebyx Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Cisplatin Injection Furosemide Disal An increased ototoxicity and an increased risk of nephrotoxicity Details Cisplatin Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Melphalan Alkeran Altered melphalan clearance Details Cisplatin Injection Paclitaxel Abraxane Increased PACLitaxel exposure Details Cisplatin Injection Paclitaxel Protein-Bound Increased PACLitaxel exposure Details Cisplatin Injection Phenytoin Dilantin Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Cisplatin Injection Rituximab Increased risk for developing renal failure Details Cisplatin Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Cisplatin Injection Tacrolimus Astagraf An increased risk of nephrotoxicity Details Cisplatin Injection Teicoplanin Increased risk of nephrotoxicity and/or ototoxicity Details Cisplatin Injection Thioctic Acid Decreased CISplatin effectiveness Details Cisplatin Injection Trilaciclib Increased plasma concentrations of CISplatin Details Cisplatin Injection Valproic Acid Depakene® Decreased valproic acid plasma concentrations and increased risk of seizures Details Cisplatin Injection Vinorelbine Navelbine An increased risk of granulocytopenia Details

Moderate

Cisplatin Injection Aldesleukin Proleukin An increased risk for hypersensitivity reactions (erythema, pruritus, hypotension) Details Cisplatin Injection Carbamazepine Carbatrol Reduced carBAMazepine exposure Details Cisplatin Injection Docetaxel Beizray Increased risk of neuropathy Details Cisplatin Injection Hydrochlorothiazide Inzirqo An increased risk of worsening of renal function Details Cisplatin Injection Lithium Reduced lithium plasma concentrations Details Cisplatin Injection Spironolactone Aldactone An increased risk of worsening of renal function Details Cisplatin Injection Tobramycin Bethkis Renal dysfunction Details Cisplatin Injection Warfarin Coumadin Increased INR Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.