Cladribine

16 interactions 157 cited references
Also sold as: Mavenclad Mavenclad®
About Cladribine

Cladribine is used to treat adults with relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control), including relapsing-remitting forms (course of dise… Read the full Cladribine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Measles Virus Vaccine, Live Varicella Virus Vaccine, Live
9 Contraindicated 7 Major
All (16) Contraindicated (9) Major (7)

Contraindicated

Cladribine Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Cladribine Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Cladribine Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Cladribine Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Cladribine Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Cladribine Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Cladribine Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cladribine Islatravir Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Cladribine Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.