Clomipramine

197 interactions 11 explained in plain English
Also sold as: Anafranil Calmera Caniquell Clomicalm
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clomipramine Besifloxacin Ophthalmic Besivance Increased risk of seizures Details Clomipramine Bepotastine Ophthalmic Bepreve Increased risk of seizures Details Clomipramine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Clomipramine Busulfan Injection Busulfex Increased risk of seizures Details Clomipramine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Clomipramine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Clomipramine Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Clomipramine Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Clomipramine Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Clomipramine Chlorambucil Leukeran Increased risk of seizures Details Clomipramine Chloroquine Aralen® An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clomipramine Cyclopentolate Ophthalmic Akpentolate® An increased risk of anticholinergic effects and an increased risk of seizures Details Clomipramine Cyclosporine Injection Atopica Increased risk of seizures Details Clomipramine Cyclosporine Ophthalmic Cequa Increased risk of seizures Details Clomipramine Dacomitinib Vizimpro Increased clomiPRAMINE exposure Details Clomipramine Dalfampridine Ampyra Increased risk of seizures Details Clomipramine Dasatinib Phyrago An increased risk of QT interval prolongation Details Clomipramine Deferasirox Exjade Increased clomiPRAMINE exposure Details Clomipramine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Clomipramine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Clomipramine Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Clomipramine Diazepam Rectal Diastat An increased risk of CNS depression Details Clomipramine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Clomipramine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Clomipramine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Clomipramine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Clomipramine Digoxin Cardoxin® Increased clomiPRAMINE exposure, an increased risk of clomiPRAMINE-related adverse effects, an increased digoxin exposure and an i... Details Clomipramine Diphenhydramine Injection Banophen Increased clomiPRAMINE exposure, an increased risk of CNS depression, increased anticholinergic effects (dry mouth, urinary retent... Details Clomipramine Diphenhydramine Topical Afterbite with Antihistamine Increased clomiPRAMINE exposure, an increased risk of CNS depression, increased anticholinergic effects (dry mouth, urinary retent... Details Clomipramine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Clomipramine Disulfiram Antabuse Increased clomiPRAMINE exposure Details Clomipramine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Clomipramine Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Clomipramine Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Clomipramine Dronabinol Marinol Increased clomiPRAMINE exposure Details Clomipramine Enasidenib Idhifa Increased clomiPRAMINE exposure Details Clomipramine Encorafenib Braftovi Increased risk of QT interval prolongation Details Clomipramine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Clomipramine Epinastine Ophthalmic Elestat® Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.