Clomipramine

197 interactions 11 explained in plain English
Also sold as: Anafranil Calmera Caniquell Clomicalm
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clomipramine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Clomipramine Abametapir Explained Increased exposure of CYP1A2 substrates Details Clomipramine Amitriptyline Elavil Explained An increased risk of QT interval prolongation, an increased risk of anticholinergic effects and an increased risk of serotonin syn... Details Clomipramine Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Clomipramine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome, an increased risk of paralytic ileus and a... Details Clomipramine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Clomipramine Dupilumab Injection Dupixent Explained Increased clomiPRAMINE exposure Details Clomipramine Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic effects and an increased risk of seizures Details Clomipramine Abemaciclib Verzenio Explained Increased clomiPRAMINE exposure Details Clomipramine Abrocitinib Cibinqo Explained Increased clomiPRAMINE exposure Details Clomipramine Acyclovir Avaclyr Increased clomiPRAMINE exposure and an increased risk of seizures Details Clomipramine Acyclovir Injection Avaclyr Increased clomiPRAMINE exposure and an increased risk of seizures Details Clomipramine Acyclovir Ophthalmic Avaclyr Increased clomiPRAMINE exposure and an increased risk of seizures Details Clomipramine Acyclovir Topical Zovirax Increased clomiPRAMINE exposure and an increased risk of seizures Details Clomipramine Alcaftadine Ophthalmic Lastacaft Increased risk of seizures Details Clomipramine Allopurinol Aloprim Increased clomiPRAMINE exposure Details Clomipramine Allopurinol Injection Aloprim Increased clomiPRAMINE exposure Details Clomipramine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Clomipramine Ampicillin Amcill® Increased risk of seizures Details Clomipramine Ampicillin Injection Omnipen-N® Increased risk of seizures Details Clomipramine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Clomipramine Aripiprazole Injection Abilify An increased risk of CNS depression and an increased risk of QT interval prolongation Details Clomipramine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Clomipramine Asenapine Transdermal Patch Secuado Increased clomiPRAMINE exposure, an increased asenapine exposure, an increased risk of QT interval prolongation and an increased r... Details Clomipramine Aspirin Acuprin® An increased risk of bleeding Details Clomipramine Aspirin Rectal Aspirin An increased risk of bleeding Details Clomipramine Atovaquone Mepron Increased risk of seizures Details Clomipramine Azathioprine Azasan An increased risk of hepatotoxicity Details Clomipramine Azithromycin AzaSite An increased risk of QT interval prolongation Details Clomipramine Aztreonam Injection Azactam Increased risk of seizures Details Clomipramine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Clomipramine Aclidinium Oral Inhalation Tudorza An increased risk of anticholinergic effects and an increased risk of seizures Details Clomipramine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Clomipramine Alogliptin Nesina Increased clomiPRAMINE exposure Details Clomipramine Amphotericin B Injection Abelcet Increased risk of seizures Details Clomipramine Anagrelide Agrylin Increased risk of QT interval prolongation Details Clomipramine Azelastine Nasal Spray Astelin® Nasal Spray Increased risk of seizures Details

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