Clomipramine
197 interactions 11 explained in plain English
Also sold as:
Anafranil
Calmera
Caniquell
Clomicalm
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Linezolid Injection
Ifosfamide Injection
Fentanyl Transdermal Patch
Dacomitinib
Major
Clomipramine Interferon Alfa-2B Injection Intron A® Increased clomiPRAMINE exposure Details Clomipramine Ivabradine Corlanor Increased risk of QT prolongation Details Clomipramine Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Clomipramine Ketoprofen Actron® An increased risk of bleeding Details Clomipramine Ketorolac Acular An increased risk of bleeding Details Clomipramine Ketorolac Injection Acular An increased risk of bleeding Details Clomipramine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Clomipramine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Clomipramine Ketotifen Alaway Increased risk of seizures Details Clomipramine Ketotifen Ophthalmic Alaway Increased risk of seizures Details Clomipramine Labetalol Normodyne® Increased clomiPRAMINE exposure Details Clomipramine Lefamulin Xenleta Increased risk of QT interval prolongation Details Clomipramine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Clomipramine Levofloxacin Levaquin An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Levofloxacin Injection Levaquin An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Levonorgestrel After banger Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Clomipramine Levonorgestrel Intrauterine System Kyleena Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Clomipramine Lindane Gamene® Increased risk of seizures Details Clomipramine Lithium Carbonate Lithobid Increased risk of seizures and an increased risk of serotonin syndrome Details Clomipramine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Clomipramine Maprotiline Ludiomil® Increased risk of seizures Details Clomipramine Meclofenamate Meclodium® An increased risk of bleeding Details Clomipramine Medroxyprogesterone Amen® Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Clomipramine Medroxyprogesterone Injection Depo-Provera Increased clomiPRAMINE exposure and an attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, a... Details Clomipramine Mefenamic Acid Ponstel® An increased risk of bleeding Details Clomipramine Mefloquine Lariam® An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Meloxicam Alloxate An increased risk of bleeding Details Clomipramine Meloxicam Injection Alloxate An increased risk of bleeding Details Clomipramine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Clomipramine Meropenem Increased risk of seizures Details Clomipramine Meropenem Injection Merrem® Increased risk of seizures Details Clomipramine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Clomipramine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Clomipramine Methylphenidate Adhansia XR® Increased clomiPRAMINE exposure, an increased risk of seizures and an increased risk of drug-drug interactions Details Clomipramine Methylphenidate Transdermal Patch Daytrana Increased clomiPRAMINE exposure, an increased risk of seizures and an increased risk of drug-drug interactions Details Clomipramine Metronidazole Flagyl An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Metronidazole Injection Flagyl An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Mexiletine Mexitil® Increased clomiPRAMINE exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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