Clomipramine

197 interactions 11 explained in plain English

Also sold as: Anafranil Calmera Caniquell Clomicalm

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Linezolid Injection Ifosfamide Injection Fentanyl Transdermal Patch Dacomitinib

3 Contraindicated 185 Major 6 Moderate 3 Minor

All (197) Contraindicated (3) Major (185) Moderate (6) Minor (3)

Major

Clomipramine Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Clomipramine Midazolam Injection Nayzilam An increased risk of CNS depression Details Clomipramine Morphine Injection Astramorph® PF An increased risk of serotonin syndrome, an increased risk of CNS depression and an increased risk of urinary retention, severe co... Details Clomipramine Moxifloxacin Avelox An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Moxifloxacin Injection Avelox An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Nabumetone Relafen An increased risk of bleeding Details Clomipramine Nafcillin Injection Unipen® Injection Increased risk of seizures Details Clomipramine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome, an increased risk of CNS depression and an increased risk of paralytic ileus Details Clomipramine Naproxen Aleve An increased risk of bleeding Details Clomipramine Neostigmine Methylsulfate Bloxiverz Increased risk of seizures Details Clomipramine Nicardipine Cardene Increased clomiPRAMINE exposure Details Clomipramine Obeticholic Acid Ocaliva Increased clomiPRAMINE exposure Details Clomipramine Octreotide Bynfezia An increased risk of QT interval prolongation Details Clomipramine Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Clomipramine Ofloxacin Floxin® An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation and an increased risk of seizures Details Clomipramine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation, an increased risk of ventricular arrhythmias and potentiated cardiovascular effects Details Clomipramine Olopatadine Pataday Increased risk of seizures Details Clomipramine Olopatadine Nasal Spray PATANASE Increased risk of seizures Details Clomipramine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Clomipramine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details Clomipramine Peginterferon Alfa-2A Injection Pegasys Increased clomiPRAMINE exposure Details Clomipramine Penicillin V Potassium Beepen-VK® Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.