Clotrimazole Vaginal

35 interactions 186 cited references

Also sold as: Gyne-Lotrimin 3® Cream Gyne-Lotrimin® Cream Trivagizole® 3 Cream

About Clotrimazole Vaginal

Vaginal clotrimazole is used to treat vaginal yeast infections in adults and children 12 years of age and older.. Clotrimazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. Read the full Clotrimazole Vaginal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Alfentanil Bedaquiline Colchicine Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome

29 Major 6 Moderate

All (35) Major (29) Moderate (6)

Major

Clotrimazole Vaginal Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Clotrimazole Vaginal Bedaquiline Sirturo Increased bedaquiline exposure Details Clotrimazole Vaginal Colchicine Colcrys Increased colchicine exposure and an increased risk of colchicine-related toxicity Details Clotrimazole Vaginal Dihydroergotamine Brekiya Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Clotrimazole Vaginal Doxorubicin Hydrochloride Liposome Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Clotrimazole Vaginal Ergoloid Mesylates Alkergot® Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Ergonovine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Ergotamine Ergomar Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Clotrimazole Vaginal Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Clotrimazole Vaginal Lemborexant Dayvigo Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Clotrimazole Vaginal Lisuride Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Lomitapide Increased lomitapide exposure Details Clotrimazole Vaginal Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Clotrimazole Vaginal Meperidine Demerol Increased meperidine exposure and risk of increased or prolonged opioid effects Details Clotrimazole Vaginal Metergoline Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Methylergonovine Methergine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Methysergide Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Mifepristone Korlym Increased miFEPRIStone exposure Details Clotrimazole Vaginal Nicergoline Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Vaginal Nifedipine Adalat® Increased NIFEdipine exposure Details Clotrimazole Vaginal Paclitaxel Abraxane Increased PACLitaxel exposure Details Clotrimazole Vaginal Paclitaxel Protein-Bound Increased PACLitaxel exposure Details Clotrimazole Vaginal Pimozide Increased pimozide exposure Details Clotrimazole Vaginal Roflumilast Daliresp Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Clotrimazole Vaginal Tacrolimus Astagraf Increased tacrolimus concentration and an increased risk of toxicity Details Clotrimazole Vaginal Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Clotrimazole Vaginal Voriconazole Vfend Increased voriconazole exposure and an increased risk of voriconazole-related adverse reaction Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.