Clotrimazole and Metergoline: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Clotrimazole
Metergoline
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia)
Interaction Deep Dive
Concomitant use of clotrimazole, a weak CYP3A4 inhibitor, and an ergot derivative may result in increased plasma concentrations of the ergot derivative due to inhibition of CYP3A4-mediated ergot metabolism. Because of the potential for serious toxicity including vasospasm can occur, use caution with the concurrent use of clotrimazole and ergot derivatives12.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated ergot metabolism by clotrimazole
Common questions
Can I take Clotrimazole and Metergoline together?
Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Clotrimazole and Metergoline interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Clotrimazole or Metergoline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: dihydroergotamine mesylate injection, dihydroergotamine mesylate injection. Paddock Laboratories,Inc, Minneapolis, MN, 2006. DailyMed
- Product Information: ERGOMAR(R) sublingual oral tablets, ergotamine tartrate sublingual oral tablets. Rosedale Therapeutics, Bristol, TN, 2003. DailyMed
Keep reading about Clotrimazole
Keep reading about Metergoline
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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