Drug Interaction Report

Clotrimazole and Paclitaxel: Interaction Details

A pharmacist-reviewed analysis of the Clotrimazole and Paclitaxel interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Clotrimazole

Aardora Anti-Fungal Maximum Strength Alevazol Clotic Cruex Antifungal Dermatin Fungicure Solution Fungistat Jock-Eze
+

Paclitaxel

Abraxane
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 38 documented Clotrimazole interactions, 31 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased PACLitaxel exposure

Interaction Deep Dive

Exercise caution when administering PACLitaxel concomitantly with CYP3A4 inhibitors as it may increase PACLitaxel exposure. PACLitaxel is a CYP3A4 substrate with a narrow therapeutic index (NTI)12. In vitro studies, PACLitaxel was found to be metabolized primarily to 2 minor metabolites, 3'-p-hydroxyPACLitaxel and 6-alpha, 3'-p-dihydroxyPACLitaxel, by CYP3A4. The pharmacokinetics of PACLitaxel may be altered as a result of interactions in vivo with compounds that are inhibitors of CYP3A4 34.

Why it happens (mechanism)

Inhibition of CYP3A4-mediated metabolism of PACLitaxel

Literature reports

1 report — tap to read

a) In vitro studies, PACLitaxel was found to be metabolized primarily to 2 minor metabolites, 3'-p-hydroxyPACLitaxel and 6-alpha, 3'-p-dihydroxyPACLitaxel, by CYP3A4. The pharmacokinetics of PACLitaxel may be altered as a result of interactions in vivo with compounds that are inhibitors of CYP3A4 34.

Common questions

Can I take Clotrimazole and Paclitaxel together?

Increased PACLitaxel exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Clotrimazole and Paclitaxel interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Clotrimazole or Paclitaxel need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Product Information: ABRAXANE(R) intravenous injection suspension, paclitaxel protein-bound particles intravenous injection suspension. Celgene Corporation (per FDA), Summit, NJ, 2020. DailyMed
  2. Product Information: TAXOL(R) IV injection, paclitaxel IV injection. Bristol-Myers Squibb Company, Princeton, NJ, 2011.
  3. Product Information: PACLITAXEL intravenous injection, paclitaxel intravenous injection. Fresenius Kabi (per Dailymed), Lake Zurich, IL, 2024. DailyMed
  4. Product Information: PACLITAXEL PROTEIN-BOUND PARTICLES (ALBUMIN-BOUND) intravenous injection lyophilized powder for suspension, paclitaxel protein-bound particles (albumin-bound) intravenous injection lyophilized powder for suspension. Sandoz Inc (per Dailymed), Princeton, NJ, 2024. DailyMed
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Clotrimazole

Keep reading about Clotrimazole

All Clotrimazole interactions (38) Clotrimazole drug information
Also serious with: Dihydroergotamine Nasal Spray Doxorubicin Hydrochloride Liposome Alfentanil Dihydroergotamine
Paclitaxel

Keep reading about Paclitaxel

All Paclitaxel interactions (41) Paclitaxel drug information
Also serious with: Octreotide Octreotide Injection Ketoconazole Topical Doxorubicin
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Clotrimazole + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Slippery Elm Tragacanth + 12 more
Paclitaxel + Activated Charcoal Apple Grapefruit St. John's Wort Sweet Orange Acacia Rigidula Adrafinil African Wild Potato + 144 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.