Clotrimazole

Name: Clotrimazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

38 interactions 186 cited references

Also sold as: Aardora Anti-Fungal Maximum Strength Alevazol Clotic Cruex Antifungal Dermatin Fungicure Solution Fungistat Jock-Eze Lasolex Liquid Lotrimin Trimazole

Read the full Clotrimazole drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Nasal Spray Ergonovine Alfentanil Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome

31 Major 7 Moderate

All (38) Major (31) Moderate (7)

Moderate

Clotrimazole Artemether Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Clotrimazole Dofetilide Tikosyn Increased dofetilide exposure Details Clotrimazole Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Clotrimazole Lumefantrine Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Clotrimazole Sirolimus Felycin An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Clotrimazole Trimetrexate Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details Clotrimazole Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.