Clozapine

114 interactions 7 explained in plain English

Also sold as: Clozaril Versacloz

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Metoclopramide Nasal Spray Metoclopramide Injection Fentanyl Transdermal Patch Estradiol Peginterferon Alfa-2A Injection

3 Contraindicated 105 Major 6 Moderate

All (114) Contraindicated (3) Major (105) Moderate (6)

Major

Clozapine Doxorubicin Adriamycin Increased clozapine plasma level and increased risk of QT prolongation Details Clozapine Encorafenib Braftovi Increased risk of QT interval prolongation Details Clozapine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Clozapine Eribulin Injection Halaven Increased risk of QT interval prolongation Details Clozapine Esketamine Nasal Spray Spravato Increased risk of sedation Details Clozapine Estradiol Delestrogen Increased clozapine exposure and increased risk of adverse effects Details Clozapine Estradiol Topical Divigel Increased clozapine exposure and increased risk of adverse effects Details Clozapine Estradiol Transdermal Patch Alora® Increased clozapine exposure and increased risk of adverse effects Details Clozapine Famotidine Calmicid Increased risk of QT interval prolongation Details Clozapine Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Clozapine Felbamate Felbatol Increased risk of QT interval prolongation Details Clozapine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Clozapine Flecainide Tambocor® Increased risk of QT interval prolongation Details Clozapine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Clozapine Fostemsavir Rukobia Increased risk of torsade de pointes Details Clozapine Galantamine Razadyne Increased risk of QT interval prolongation Details Clozapine Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details Clozapine Gemifloxacin Factive Increased risk of QT interval prolongation Details Clozapine Glasdegib Daurismo Increased risk of QT interval prolongation Details Clozapine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Clozapine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Clozapine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Clozapine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Clozapine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Clozapine Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Clozapine Granisetron Injection Granisol Increased risk of QT interval prolongation Details Clozapine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Clozapine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Clozapine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Clozapine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Clozapine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Clozapine Interferon Alfa-2B Injection Intron A® Increased clozapine exposure Details Clozapine Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Ipratropium Oral Inhalation Atrovent® HFA Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Clozapine Ivabradine Corlanor Increased risk of QT interval prolongation Details Clozapine Lacosamide Injection Motpoly An increased risk of CNS depression Details Clozapine Lefamulin Xenleta Increased risk of QT interval prolongation Details Clozapine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Clozapine Letermovir Injection Prevymis Increased cloZAPine exposure Details Clozapine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details

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